FAST PHOTOCHEMICAL OXIDATION OF BETA LACTOGLOBULIN AND DECTIN-1

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究使用了β-乳球蛋白(BLG)，因为它是一种已知的 快速折叠的蛋白质，在氧化时会展开。如果FPOP为 适当淬火时，BLG在氧化态之间的分布应 用泊松分布建模。如果展开发生在 氧化的时间尺度，则分布应呈现非泊松分布 特性--蛋白质连续氧化的概率不是 与之前的氧化无关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study uses beta lactoglobulin (BLG) because it is known to be a fast-folding protein which suffers unfolding upon oxidation. If FPOP is properly quenched, the distribution of BLG among oxidation states should be modeled by a Poisson distribution. If unfolding occurs on the timescale of oxidation, then the distribution should exhibit a non-Poisson character--the probability of a successive oxdiation of a protein is not independent of it previous oxidation.