QUANTITATION OF OXIDATION-INDUCED CONFORMATIONAL CHANGES BY 2ND ORDER REACTIONS
QUANTITATION OF OXIDATION-INDUCED CONFORMATIONAL CHANGES BY 2ND ORDER REACTIONS
批准号:
8168866
负责人:
JOSHUA S SHARP
金额:
$0.17万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-04-10 至 2011-01-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Recently, a method for hydroxyl radical footprinting using flash fast photooxidation of proteins (FPOP) was published that claims to complete the oxidation chemistry faster than the protein can undergo a significant oxidation-induced unfolding. Unfortunately, the methods for verifying this claim were indirect in nature, by comparing sites of oxidation with published high resolution structures. In order to verify that the FPOP method can complete oxidation chemistry faster than the protein can unfold, we are developing a method for detecting and quantitating the amount of oxidation-induced unfolding that occurs during a second order hydroxyl radical footprinting experiment using analysis of the intact protein oxidation products.
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会议论文
FRAGMENTATION PROPERTIES OF OXIDIZED PEPTIDES BY ERGODIC & NON-ERGODIC METHODS
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批准号:8361802
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项目类别:
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资助金额:$3.54万
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财政年份:2011
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负责人:JOSHUA S SHARP
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依托单位:
HYDROXYL RADICAL FOOTPRINTING OF ESTROGEN RECEPTOR-LIGAND & INHIBITOR COMPLEXES
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批准号:8361824
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项目类别:
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资助金额:$0.18万
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财政年份:2011
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负责人:JOSHUA S SHARP
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依托单位:
RADICAL FOOTPRINTING BY SUB-MICROSECOND ELECTRON BEAM PULSE
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批准号:8361800
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项目类别:
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资助金额:$3.54万
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财政年份:2011
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负责人:JOSHUA S SHARP
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依托单位:
AN IMPROVED SEARCH ALGORITHM FOR AUTOMATED IDENTIFICATION OF OXIDATION SITES
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批准号:8361803
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项目类别:
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资助金额:$3.54万
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财政年份:2011
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负责人:JOSHUA S SHARP
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依托单位:
STRUCTURAL CONSEQUENCES OF ROS DAMAGE ON A MODEL SIGNAL TRANSDUCTION PROTEIN
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批准号:8361801
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项目类别:
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资助金额:$3.54万
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财政年份:2011
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负责人:JOSHUA S SHARP
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依托单位:
METHIONINE SULFOXIDE REDUCTASE REPAIR OF CATALASE IN HELIOBACTER PYLORI
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批准号:8361818
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项目类别:
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资助金额:$0.18万
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财政年份:2011
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负责人:JOSHUA S SHARP
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依托单位:
FRAGMENTATION PROPERTIES OF OXIDIZED PEPTIDES BY ERGODIC & NON-ERGODIC METHODS
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批准号:8168865
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项目类别:
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资助金额:$3.37万
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财政年份:2010
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负责人:JOSHUA S SHARP
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依托单位:
AN IMPROVED SEARCH ALGORITHM FOR AUTOMATED IDENTIFICATION OF OXIDATION SITES
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批准号:8168869
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项目类别:
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资助金额:$3.37万
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财政年份:2010
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负责人:JOSHUA S SHARP
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依托单位:
STRUCTURAL CONSEQUENCES OF ROS DAMAGE ON A MODEL SIGNAL TRANSDUCTION PROTEIN
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批准号:8168864
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项目类别:
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资助金额:$3.37万
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财政年份:2010
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负责人:JOSHUA S SHARP
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依托单位:
PROTEIN HYDROPEROXIDES AS SECONDARY OXIDANTS IN HYDROXYL RADICAL FOOTPRINTING
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批准号:8168868
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项目类别:
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资助金额:$3.37万
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财政年份:2010
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负责人:JOSHUA S SHARP
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依托单位:
RADICAL FOOTPRINTING BY SUB-MICROSECOND ELECTRON BEAM PULSE
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批准号:8168862
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项目类别:
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资助金额:$3.37万
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财政年份:2010
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负责人:JOSHUA S SHARP
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依托单位:
METHIONINE SULFOXIDE REDUCTASE REPAIR OF CATALASE IN HELIOBACTER PYLORI
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批准号:8168899
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项目类别:
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资助金额:$0.17万
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财政年份:2010
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负责人:JOSHUA S SHARP
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依托单位:
HYDROXYL RADICAL FOOTPRINTING OF DECTIN CARBOHYDRATE BINDING SURFACE
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批准号:8168863
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项目类别:
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资助金额:$0.17万
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财政年份:2010
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负责人:JOSHUA S SHARP
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依托单位:
ELECTRON CAPTURE DISSOCIATION FOR DETERMINING H/D EXCHANGE RATES IN PEPTIDES
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批准号:8168867
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项目类别:
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资助金额:$3.37万
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财政年份:2010
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负责人:JOSHUA S SHARP
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依托单位:
FAST PHOTOCHEMICAL OXIDATION OF BETA LACTOGLOBULIN AND DECTIN-1
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批准号:8168729
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项目类别:
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资助金额:$1.28万
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财政年份:2010
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负责人:JOSHUA S SHARP
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依托单位:
RADICAL FOOTPRINTING BY SUB-MICROSECOND ELECTRON BEAM PULSE
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批准号:7957534
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项目类别:
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资助金额:$3.29万
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财政年份:2009
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负责人:JOSHUA S SHARP
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依托单位:
QUANTITATION OF OXIDATION-INDUCED CONFORMATIONAL CHANGES BY 1ST ORDER REACTIONS
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批准号:7957537
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项目类别:
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资助金额:$3.29万
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财政年份:2009
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负责人:JOSHUA S SHARP
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依托单位:
PROTEIN HYDROPEROXIDES AS SECONDARY OXIDANTS IN HYDROXYL RADICAL FOOTPRINTING
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批准号:7957558
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项目类别:
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资助金额:$3.29万
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财政年份:2009
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负责人:JOSHUA S SHARP
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依托单位:
FAST PHOTOCHEMICAL OXIDATION OF BETA LACTOGLOBULIN AND DECTIN-1
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批准号:7953961
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项目类别:
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资助金额:$0.93万
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财政年份:2009
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负责人:JOSHUA S SHARP
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依托单位:
ELECTRON CAPTURE DISSOCIATION FOR DETERMINING H/D EXCHANGE RATES IN PEPTIDES
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批准号:7957557
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项目类别:
-
资助金额:$3.29万
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财政年份:2009
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负责人:JOSHUA S SHARP
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依托单位: