SPECIFICITY OF HISTONE ACETYLTRANSFERASE ENZYMES FROM ARABIDOPSIS THALIANA
拟南芥组蛋白乙酰转移酶的特异性
基本信息
- 批准号:7953917
- 负责人:
- 金额:$ 0.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-02-01 至 2010-01-31
- 项目状态:已结题
- 来源:
- 关键词:Binding ProteinsBiochemicalBiochemistryChromatinComputer Retrieval of Information on Scientific Projects DatabaseCytogeneticsDNADNA MethylationDNA MethyltransferaseDNA Modification MethylasesEnzymesEpigenetic ProcessFundingGene SilencingGene TargetingGenesGeneticGenetic TechniquesGrantHistonesInstitutionMass Spectrum AnalysisModelingMolecular BiologyMouse-ear CressPathway interactionsPlantsPlayRNA InterferenceRepressionResearchResearch PersonnelResearch Project GrantsResourcesRoleSmall RNASourceSpecificityUnited States National Institutes of Healthbiomedical resourcechromatin modificationchromatin proteinhistone acetyltransferasehistone modificationknock-downrRNA Genes
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
The Pikaard lab studies the ways genes are activated and repressed, using techniques of genetics, biochemistry and molecular biology. Our current research projects are focused on gene silencing and the role that chromatin proteins and small RNAs (siRNAs) play in these epigenetic phenomena. the research focuses on plants, the important one for this project is Arabidopsis thaliana.
Inactive rRNA genes are silenced via chromatin modifications. rRNA gene silencing involves concerted changes in both DNA methylation and histone modification and we have proposed a model whereby DNA and histone modifications are each upstream of one another in a self-reinforcing, circular pathway. The Pikaard group wishes to identify the chromatin modifying activities involved in this repression cycle, using RNA-interference to knock down the expression of targeted genes. Two histone deacetylases, one DNA methyltransferase and several methylcytosine binding proteins have been identified in the screens thus far. We are making use of a variety of genetic, cytogenetic and biochemical approaches in order to understand the mechanism(s) of action of these chromatin modifying activities and to understand how their actions are intertwined to comprise an epigenetic on-off switch
这个子项目是众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CRAIG Stuart PIKAARD其他文献
CRAIG Stuart PIKAARD的其他文献
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{{ truncateString('CRAIG Stuart PIKAARD', 18)}}的其他基金
SPECIFICITY OF HISTONE ACETYLTRANSFERASE ENZYMES FROM ARABIDOPSIS THALIANA
拟南芥组蛋白乙酰转移酶的特异性
- 批准号:
7721482 - 财政年份:2008
- 资助金额:
$ 0.06万 - 项目类别:
Roles of RNA Polymerases IV and V in siRNA-mediated gene silencing
RNA 聚合酶 IV 和 V 在 siRNA 介导的基因沉默中的作用
- 批准号:
8391724 - 财政年份:2006
- 资助金额:
$ 0.06万 - 项目类别:
Role of RNA polymerase IV in the heterochromatic siRNA pathway
RNA聚合酶IV在异染色质siRNA途径中的作用
- 批准号:
7599659 - 财政年份:2006
- 资助金额:
$ 0.06万 - 项目类别:
Roles of RNA Polymerases IV and V in siRNA-mediated gene silencing
RNA 聚合酶 IV 和 V 在 siRNA 介导的基因沉默中的作用
- 批准号:
8204558 - 财政年份:2006
- 资助金额:
$ 0.06万 - 项目类别:
Role of RNA polymerase IV in the heterochromatic siRNA pathway
RNA聚合酶IV在异染色质siRNA途径中的作用
- 批准号:
8037901 - 财政年份:2006
- 资助金额:
$ 0.06万 - 项目类别:
SPECIFICITY OF HISTONE ACETYLTRANSFERASE ENZYMES FROM ARABIDOPSIS THALIANA
拟南芥组蛋白乙酰转移酶的特异性
- 批准号:
7355309 - 财政年份:2006
- 资助金额:
$ 0.06万 - 项目类别:
Role of RNA polymerase IV in the heterochromatic siRNA pathway
RNA聚合酶IV在异染色质siRNA途径中的作用
- 批准号:
7088118 - 财政年份:2006
- 资助金额:
$ 0.06万 - 项目类别:
Role of RNA polymerase IV in the heterochromatic siRNA pathway
RNA聚合酶IV在异染色质siRNA途径中的作用
- 批准号:
7220652 - 财政年份:2006
- 资助金额:
$ 0.06万 - 项目类别:
Roles of RNA Polymerases IV and V in siRNA-mediated gene silencing
RNA 聚合酶 IV 和 V 在 siRNA 介导的基因沉默中的作用
- 批准号:
8041251 - 财政年份:2006
- 资助金额:
$ 0.06万 - 项目类别:
Role of RNA polymerase IV in the heterochromatic siRNA pathway
RNA聚合酶IV在异染色质siRNA途径中的作用
- 批准号:
7410175 - 财政年份:2006
- 资助金额:
$ 0.06万 - 项目类别:
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