Study Of Trial Policy Of Interim Trucation-2 (STOP-IT-2)

临时休学试行政策研究-2（STOP-IT-2）

• 批准号: G0600561/1
• 负责人: Paul Glasziou
• 金额: $ 28.33万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0600561%2F1
• 关键词: Study; Trial; Policy; Interim; Trucation

A recent review 143 randomized trials that stopped earlier than planned because of a larger than expected treatment effect showed that such trials are increasingly common but often show implausibly large treatment effects. This study (STOP IT-2) aims to understand how biased such early stopping is, and how we might fix the problem. To do this we will find and summarise all other research trials that answer the same questions as those that stopped early and compare the results. The results will have considerable importance to the interpretation of trials that stop early, and will help clinicians, policy makers and consumers in interpreting such trials.

最近的一项综述显示，由于治疗效果大于预期而提前停止的143项随机试验表明，此类试验越来越常见，但往往显示出令人难以置信的巨大治疗效果。这项研究(停止IT-2)旨在了解这种提前停止的偏见有多大，以及我们如何解决这个问题。为了做到这一点，我们将找到并总结所有其他研究试验，这些试验回答的问题与那些提前停止的试验相同，并比较结果。这一结果将对解释提前停止的试验具有相当重要的意义，并将帮助临床医生、政策制定者和消费者解释此类试验。