The role of MARCH1 in the ubiquitination and regulation of surface immunoreceptors

我们正在努力寻找体内细胞躲避免疫系统的方法，这可能会使它们发展成癌症。为了防止细胞癌变并允许细胞正常生长，所有细胞的表面都有受体。这些受体需要严格控制。在这些受体上添加被称为泛素的小标签会导致它们被移除。疱疹病毒设计了巧妙的方法，将泛素标签添加到重要的细胞表面受体上，导致受体被移除。病毒很狡猾，从我们自己的细胞中窃取了这个想法。这导致了一个新的基因家族的发现--称为马奇家族。我们发现Marchs在调节免疫系统的受体方面发挥着重要作用。我们的初步证据表明，3月蛋白控制着免疫细胞的活动，以确保细胞既不过度活跃也不过度活跃。我们将使用现代分子技术来了解MARCH蛋白是如何控制细胞表面受体的。这对于了解(I)免疫细胞如何工作，(Ii)MARCH蛋白是否将成为预防免疫介导性疾病的良好药物靶点，以及(Iii)它们是否允许细胞逃离免疫系统而发展为癌症将是重要的。

We are trying to find ways in which cells in our body hide from our immune system, which may allow them to develop into cancers. To prevent a cell becoming cancerous and allow normal cell growth, all cells have receptors at their surface. These receptors need to be tightly controlled. The addition of small tags called ubiquitin onto these receptors causes their removal. Herpesviruses have devised ingenious ways of adding ubiquitin tags to important cell surface receptors, leading to the receptors’ removal. Viruses are cunning and stole this idea from our own cells. This led to the discovery of a new family of genes –called the MARCH family. We found that MARCHs play an important role in regulating receptors of our immune system. Our preliminary evidence suggests that MARCH proteins control immune cell activity to ensure that cells are neither over- nor under-active. We will use modern molecular techniques to find out how MARCH proteins control cell surface receptors.This will be important for learning about (i) how immune cells work (ii) whether MARCH proteins will be good drug targets to prevent immune-mediated disease and (iii) whether they allow cells to escape the immune system and develop into cancers.