"VON WILLEBRAND DISEASE AND ANGIODYSPLASIA: THE ROLE OF VON WILLEBRAND FACTOR IN VESSEL FORMATION"

“血管性血友病和血管发育不良：血管性血友病因子在血管形成中的作用”

• 批准号: G0600868/1
• 负责人: Anna Randi
• 金额: $ 50.13万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0600868%2F1
• 关键词: VON; WILLEBRAND; DISEASE; ANGIODYSPLASIA; ROLE

Repair and formation of new blood vessels is a central process in health and disease. We propose that von willebrand factor, a blood protein made in the lining of blood vessels, plays an important role in regulating this process. Production of von willebrand factor is extremely variable in the population and thus may be an important contributor to disease. We have preliminary evidence that this can be observed and investigated using cells isolated from routine blood samples.

新血管的修复和形成是健康和疾病的中心过程。我们认为血管性血友病因子（vonwillebrand factor），一种在血管内壁产生的血液蛋白，在调节这一过程中起着重要作用。血管性血友病因子的产生在人群中变化很大，因此可能是疾病的重要因素。我们有初步证据表明，这可以观察到，并使用从常规血液样本中分离的细胞进行研究。