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Modeling response to P13K Target Therapies

Modeling response to P13K Target Therapies
对 P13K 靶向治疗的反应进行建模
批准号：
8181894
负责人：
GORDON B. MILLS
金额：
$56.25万
依托单位：
UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-05-01 至 2015-02-28
来源：
https://reporter.nih.gov/project-details/8181894
关键词：
1-Phosphatidylinositol 3-KinaseAKT2 geneAddressAffectApoptosisBRAF geneBackBioenergeticsBiologicalBreast Cancer CellBypassCell Cycle ProgressionCell ProliferationCell SizeCell Surface ReceptorsCell physiologyCerealsClinical TrialsComplexComputer SimulationDataDevelopmentDrug CombinationsDrug Delivery SystemsElementsEnergy-Generating ResourcesEnsureEpidermal Growth Factor ReceptorFamilyFeedbackGenerationsGenomicsGlycolysisGoalsHomeostasisImageryInterventionInvestigationKnowledgeMEKsMalignant NeoplasmsMapsMediatingMetabolismModelingMolecularMutationNatureNetwork-basedOncogenicOutcomePDPK1 genePTEN geneParticipantPathway interactionsPatientsPharmaceutical PreparationsPhasePhosphoproteinsPhosphotransferasesPhysiologicalProcessPropertyProtein Array AnalysisProtein BiosynthesisProtein IsoformsProteinsProto-Oncogene Proteins c-aktSeriesSignal PathwaySignal TransductionSirolimusSmall Interfering RNASourceStructureSystemTSC1 geneTSC2 geneTestingTherapeutic InterventionTimeValidationWarburg Effectbaseblood glucose regulationcell motilitycombinatorialdesignfeedingglucose uptakehuman FRAP1 proteininhibitor/antagonistknock-downmTOR Inhibitormalignant breast neoplasmmathematical modelmembermulti-scale modelingnovelpredictive modelingprogramsprotein complexresearch studyresponsestem cell divisiontherapeutic targettumortumor initiationtumorigenesis

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