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Collaborative Pediatric Critical Care Research Network

儿科重症监护协作研究网络

基本信息

批准号：
7784258
负责人：
KATHLEEN L. MEERT
金额：
$ 28.12万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-05-01 至 2014-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7784258
关键词：
Address Admission activity Applied Research Area Arousal Beds Behavioral Burn injury Caring Cessation of life Characteristics Child Child Development Child Traumatic Stress Childhood Children&apos s Oncology Group Chronic Clinical Clinical Trials Communities Critical Care Critical Illness Critically ill children Decision Making Demographic Factors Development Diagnostic Disease Education Effectiveness Emergency Care Environment Epidemiologic Studies Event Exposure to Failure Family Foundations Future Genetic Goals Grief reaction Health Hospitalized Child Human Inflammation Informatics Injury Intensive Care Intervention Knoll brand of cerivastatin sodium Knowledge Lead Length of Stay Life Literature Malignant Neoplasms Medical Mental Health Michigan Modeling Natural Disasters Neonatal Nutrient Organ Transplantation Outcome Pain Parents Patients Pediatric Hospitals Pharmaceutical Preparations Post-Traumatic Stress Disorders Prevalence Preventive Intervention Procedures Productivity Psyche structure Psychological adjustment Public Health Randomized Controlled Trials Recording of previous events Recruitment Activity Research Research Personnel Research Priority Residual state Resuscitation Risk Risk Factors Safety Sample Size Schools Scientist Screening procedure Sepsis Series Site Societies Stimulus Stress Survivors Symptoms Testing The Sun Translational Research Trauma Universities Variant Violence Vulnerable Populations Work assault base biological adaptation to stress clinically relevant cohort design disorder risk experience fetal follow-up high risk improved innovation longitudinal design meetings mortality multidisciplinary neglect pediatric pharmacology prevent psychologic psychosocial public health relevance racial and ethnic randomized trial resilience success tool vehicular accident ward

项目摘要

DESCRIPTION (provided by applicant): The aim of this application is for Children's Hospital of Michigan (CHM), Wayne State University (WSU) to continue in the Collaborative Pediatric Critical Care Research Network (CPCCRN). During its first cycle, the CPCCRN initiated a wide range of research including epidemiologic studies of life-threatening illnesses; descriptive studies of inflammation and sepsis; randomized trials of nutrients, drugs, and resuscitation interventions; informatics-based decision-making; genetic studies; and behavioral studies of the effects of critical illness on the family. Kathleen Meert, MD, PI for the CPCCRN at WSU during its first cycle and for the proposed cycle, is a pediatric intensivist with a wealth of clinical and translational research experience. The PICU at CHM is a 30 bed, multidisciplinary unit that cares for 1,500 patients/year with diverse racial and ethnic backgrounds. Strengths of WSU include its experience in the Neonatal Network, the Maternal-Fetal Network, the Pediatric Emergency Care Applied Research Network, the Pediatric Pharmacology Research Unit and the Children's Oncology Group, and its success with long-term follow-up of patients in clinical trials. Survival of children with disabling residuals of critical illness is increasing; thus long-term follow-up has become a top research priority. Disabling residuals include chronic psychological conditions such as post- traumatic stress symptoms (PTSS) and disorder (PTSD). The concept proposal for this application will determine the prevalence of and risk and resilience factors for PTSS and PTSD in children exposed to the PICU for treatment of critical illness; and develop a PICU screening tool to identify children at high risk for PTSS and PTSD. The central hypothesis is that children often experience their PICU stay as a traumatic event that can lead to PTSS and PTSD, and that risk and resilience factors can be identified during the PICU stay. The hypothesis will be tested by pursuing 3 specific aims: (1) Determine the prevalence of PTSS and PTSD after critical illness in children; (2) Identify predictors of PTSS and PTSD in critically ill children; and (3) Develop a PICU screening tool for PTSS and PTSD. The concept proposal is significant because it will lay a foundation for definitive studies of preventive interventions for critically ill children at risk of PTSS and PTSD. PUBLIC HEALTH RELEVANCE: The research is relevant to public health because it will allow screening for PTSS and PTSD to become a regular part of PICU care, and provide a basis for developing effective preventive interventions. Identifying and preventing psychological problems that result from critical illness will facilitate children's development, education, reintegration into family, school and community, and future productivity within society at large.

描述（由申请人提供）：本申请的目的是让密歇根儿童医院（CHM）、韦恩州立大学（WSU）继续参与协作儿科重症监护研究网络（CPCCRN）。在其第一个周期，CPCCRN发起了广泛的研究，包括危及生命的疾病的流行病学研究;炎症和败血症的描述性研究;营养素，药物和复苏干预的随机试验;基于信息的决策;遗传研究;和危重病对家庭影响的行为研究。Kathleen Meert，MD，WSU CPCCRN第一个周期和拟定周期的PI，是一名儿科重症监护医师，具有丰富的临床和转化研究经验。CHM的PICU是一个30张病床的多学科单位，每年照顾1，500名不同种族和民族背景的患者。WSU的优势包括其在新生儿网络，母婴网络，儿科急诊应用研究网络，儿科药理学研究单位和儿童肿瘤学小组的经验，以及其在临床试验中长期随访患者的成功。患有严重疾病致残残馀的儿童的存活率正在增加，因此长期随访已成为研究的重中之重。致残性残留物包括慢性心理状况，如创伤后应激障碍（PTSS）和创伤后应激障碍（PTSD）.该应用的概念提案将确定暴露于PICU治疗危重疾病的儿童中PTSS和PTSD的患病率以及风险和弹性因素;并开发PICU筛查工具以识别PTSS和PTSD高风险儿童。核心假设是，儿童经常经历他们的PICU停留作为一个创伤性事件，可导致PTSS和PTSD，并在PICU停留期间可以确定风险和弹性因素。该假设将通过追求3个具体目标进行检验：（1）确定儿童危重病后PTSS和PTSD的患病率;（2）确定危重病儿童PTSS和PTSD的预测因子;（3）开发PTSS和PTSD的PICU筛查工具。这一概念提案意义重大，因为它将为有PTSS和PTSD风险的重症儿童的预防性干预措施的确定性研究奠定基础。公共卫生相关性：这项研究与公共卫生有关，因为它将使PTSS和PTSD筛查成为PICU护理的常规部分，并为制定有效的预防干预措施提供基础。查明和预防因重大疾病而产生的心理问题，将有助于儿童的发展、教育、重新融入家庭、学校和社区，以及今后在整个社会中的生产力。