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Cyclotron and Radiochemistry

回旋加速器和放射化学

基本信息

批准号：
7899928
负责人：
RONALD D FINN
金额：
$ 12.11万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7899928
关键词：
Academic Medical Centers Acceleration Antibodies Applications Grants Area Arts Award Back Belief Biological Canada Cancer Center Cancer Research Project Carbon Cell Survival Cells Charge Chemicals Chemistry Chloride Ion Chlorides Clinical Clinical Protocols Collaborations Core Facility Custom Cyclotrons Development Engineering Failure Fluorides Funding Gases Gene Expression Goals Grant Half-Life Hour Human Resources Image Immunology Individual Iodides Iodine Ionizing radiation Ions Isotopes Japan Label Laboratories Learning Life Linear Energy Transfer Location Lodine Longevity Malignant Neoplasms Medical Memorial Sloan-Kettering Cancer Center Methionine Methods Minor Modification Molybdenum National Center for Research Resources Neurologic Neutrons Nitrogen Nucleosides Operations Research Operative Surgical Procedures Oxides Peer Review Positron Postdoctoral Fellow Preparation Principal Investigator Procedures Production Protons Publications Raclopride Radio Radiochemistry Radioisotopes Radiolabeled Radiopharmaceuticals Recovery Research Research Infrastructure Research Personnel Resources Schedule Scientist Services Side Solid Spiperone Staging Steel Synthesis Chemistry System Targeted Research Technetium Technology Time Tracer Universities Variant Work Yttrium base bioimaging clinical application cost design deuteron experience fialuridine improved in vivo Cellular and Molecular Imaging Centers instrument instrumentation interest irradiation man medical schools member molecular imaging novel particle particle beam programs quality assurance radiochemical radioligand radiotracer small molecule

项目摘要

The Memorial Sloan-Kettering cyclotron/radiochemistry resource provides infrastructure for radionuclide production, radiochemical synthesis, and radio antibody preparation for the five projects, and 2 developmental projects of the ICMIC renewal. The resource includes state-of-the-art facilities, such as the EBCO 19/9 cyclotron and associated radiochemistry support facilities including hot cells and hoods which are located in a state-of-the-art shared facility with Weill Cornell University medical Center. This facility produces most of the research radionuclides including F-18 fluoride and F-18 F-2 gas, carbon 11, technetium-94m, yttrium 86, and lodine-124. In particular, successful production of significant quantities of Iodine124 in a variety of radiopharmaceutical forms is a kind of signature product for the resource. Also at this facility, automated procedures for the production of FDG, and C11 methionine are carried out. Radiochemistry support facilities including hot cells are also available at Memorial Sloan-Kettering cancer central isotope laboratory, and the longer live radionuclides and custom center syntheses are performed in facilities on campus after transport from the Weill Cornell facility. A diverse variety of radioligands produced by the Resource support a broad set of projects, including gene expression imaging with a nucleoside substrates, FEAU and FIAU, labeled with both F-18 and lodine-124. In addition novel small molecules and antibodies have also been produced for the first time at MSKCC Sloan-Kettering cancer center by the Resource, particularly in positron emitting form. A total of 18 custom radiopharmaceuticals have been synthesized and will be available for the special needs of the ICMIC scientists. Of these, it is anticipated that all of these will be prepared in a form suitable for use in man.

纪念斯隆-凯特琳回旋加速器/放射化学资源为放射性核素提供基础设施生产、放射化学合成、放射性抗体制备5个项目， ICMIC更新的发展项目。该资源包括最先进的设施，如 EBCO 19/9回旋加速器和相关的放射化学支持设施，包括热室和罩，位于与威尔康奈尔大学医学中心的最先进的共享设施。这个设施产生大多数研究放射性核素，包括F-18氟化物和F-18 F-2气体，碳11，锝-94M，钇86和碘-124。特别是，成功地生产了大量的碘124以各种放射性药物形式存在，是该资源的一种标志性产品。也在在该设施中，进行用于生产FDG和C11甲硫氨酸的自动化程序。放射化学支持设施，包括热室也可在纪念斯隆-凯特琳癌症中心同位素实验室，以及更长寿命的放射性核素和定制中心合成在从威尔康奈尔设施运输后，校园内的设施。产生的各种放射性配体由资源支持一系列广泛的项目，包括基因表达成像与核苷用F-18和碘-124标记的底物FEAU和FIAU。此外，新的小分子和 MSKCC斯隆-凯特琳癌症中心也首次生产了抗体，资源，特别是正电子发射形式的资源。共有18种定制放射性药物已被这些材料将被合成，并将可用于ICMIC科学家的特殊需要。其中，预计所有这些都将以适用于人的形式制备。