Characterization of sequence specificities and structures of QNEs

QNE 的序列特异性和结构表征

• 批准号: 7904630
• 负责人: ABRAHAM PINTER
• 金额: $ 42.8万
• 依托单位: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7904630
• 关键词: Address; Advisory Committees; Agreement; Amino Acids; Antibodies; Antigens; Binding; Biochemical; Biological Assay; Carbohydrates; Chimera organism; Communication; Crystallization; DNA Sequence Rearrangement; Dependence; Epitopes; Funding Mechanisms; Genetic Complementation Test; Goals; HIV Envelope Protein gp120; HIV-2; Human Resources; Immune Sera; Individual; Institution; Intellectual Property; Learning; Legal; Location; Macaca mulatta; Maps; Masks; Mediation; Modeling; Molecular; Molecular Cloning; Molecular Conformation; Monitor; Monkeys; Mutation; Preparation; Property; Proteins; Publications; Reagent; Reporting; Resistance; Scientist; Screening procedure; Serum; Site; Site-Directed Mutagenesis; Son of Sevenless Proteins; South Africa; Specificity; Structure; Testing; U-Series Cooperative Agreements; United States National Institutes of Health; Vertebral column; Viral; Viral Proteins; Work; disulfide bond; env Gene Products; immunogenicity; member; mutant; neutralizing antibody; novel; programs; research study; scaffold; simian human immunodeficiency virus; simulation; vector

The Administrative core will be responsible for the overall management of this HIVRAD. This Core will be responsible for interacting with DAIDS Program Officer and Staff as required by the funding mechanism as a multi-project cooperative agreement between our team and the NIH. The Core will coordinate all aspects of routine program management on administrative, financial, and regulator issues. The Administrative Core will also organize and interact with external advisors, and host annual external reviews. This Core has the following four Specific Aims: 1- To coordinate the interactions a) among scientists from different institutions included in the current program and b) between our team and Scientific Advisory Board members and NIH personnel regarding efficient implementation of the proposed plans and projects. 2- To oversee budgetary matters, including review and approval of subcontractual agreements, monitoring of monthly expenses and preparation of various reports. 3- To develop an Intellectual Property plan and provide logistical support for intellectual property filings and negotiations 4- To coordinate publications and presentations of results arising from these studies.

行政核心将负责全面管理艾滋病毒防治和资源调配系统。这一核心将是 负责按照资助机制的要求，与DAIDS项目官员和工作人员进行互动， 我们的团队和NIH之间的多项目合作协议。核心将协调 管理行政、财务和监管问题的日常项目管理。行政核心将 还组织外部顾问并与之互动，并主持年度外部审查。 该核心有以下四个具体目标： 1-（a）协调来自当前研究所的不同机构的科学家之间的相互作用， 计划和B）我们的团队和科学顾问委员会成员和NIH人员之间关于有效实施拟议的计划和项目。 2-监督财政预算事宜，包括审核及批核分判合约、监察每月开支及拟备各类报告。 3-制定知识产权计划，并为知识产权申请和谈判提供后勤支持 4-协调这些研究结果的出版和介绍。