Hearing Impairment in HIV/AIDS

描述（由申请人提供）：我们正在提议一项为期5年的研究，以了解hiv感染者中听力障碍的患病率和病理生理学，包括长期抗逆转录病毒治疗的效果。我们计划检验感染HIV的个体经历听觉功能障碍的假设，这种损害可能与疾病阶段和长期使用抗逆转录病毒治疗有关。我们将研究以下具体目标：1。与未感染HIV-1的对照组相比，评估HIV-1感染者中听力损伤的患病率和类型，并确定衰老对这些群体中听觉功能的影响。我们假设感染HIV-1的个体会经历听觉障碍。HIV-1可能直接影响耳蜗、八神经或中枢听觉系统。我们预计HIV-1感染的患者可能在生命早期与未感染的对照组相比听觉功能受损。2. 确定HIV-1疾病阶段对HIV-1感染者听觉损伤的影响。我们假设听力障碍在HIV-1感染的HIV晚期患者中比在HIV早期患者中更为普遍。我们预计，没有病毒学抑制的症状性HIV-1感染个体的听觉功能会比持续病毒学控制的患者更差。3. 确定抗逆转录病毒药物对听力功能的影响。我们假设长期使用抗逆转录病毒药物影响听力，可能是通过线粒体毒性和氧化过程的改变，这在某些方面可能类似于糖尿病对听觉系统的负面影响。一般来说，听力障碍与经济生产力下降、生活质量下降、抑郁、功能状态下降和社会孤立有关。保持沟通地位和社会互动对劳动力的生产力和个人福祉至关重要。此外，听力障碍可能妨碍与卫生保健提供者的口头交流，干扰理解和遵守医疗建议，并妨碍坚持对成功治疗艾滋病毒/艾滋病至关重要的药物。公共卫生相关性：听力障碍与经济生产力下降、生活质量下降、抑郁、功能状态下降和社会孤立有关。保持沟通地位和社会互动对劳动力的生产力和个人福祉至关重要。此外，听力障碍可能妨碍与卫生保健提供者的口头交流，干扰理解和遵守医疗建议，并妨碍坚持对成功治疗艾滋病毒/艾滋病至关重要的药物。

DESCRIPTION (provided by applicant): We are proposing a 5-year study to understand the prevalence and pathophysiology of hearing impairment in HIV-infected men and women, including the effect of long-term antiretroviral therapy. We plan to examine the hypothesis that individuals infected with HIV experience auditory dysfunction and that this impairment may be associated with disease stage and long- term use of antiretroviral therapy. We will examine the following specific aims: 1. Assess the prevalence and types of hearing impairment in individuals infected with HIV-1 compared to uninfected controls and define the effects of aging on auditory function in these groups. We hypothesize that individuals infected with HIV-1 will experience auditory dysfunction. HIV-1 may cause a direct effect on the cochlea, eight nerve or central auditory system. We anticipate that HIV-1 infected patients may have impairment of auditory function earlier in life compared to uninfected controls. 2. Determine the influence of HIV-1 disease stage on auditory impairment in HIV-1 infected individuals. We hypothesize that hearing impairment will be more prevalent among HIV-1 infected individuals at advanced stages of HIV disease compared to individuals at earlier stages of the disease. We expect that individuals with symptomatic HIV-1 infection without virologic suppression will have worse auditory function than patients with sustained virologic control. 3. Determine the influence of antiretroviral medications on hearing function. We hypothesize that long-term use of antiretroviral medications affects hearing, possibly through mitochondrial toxicity and changes in the oxidative process, which may be similar, in some ways, to the negative effects of diabetes on the auditory system. In general, hearing impairment is associated with a decreased economic productivity, decreased quality of life, depression, reduced functional status and social isolation. Preserving communicational status and social interactions are crucial for productivity in the work force and personal well being. In addition, hearing impairment may prevent verbal communication with health care providers, interfere with understanding and compliance for medical recommendations and hinder adherence to medications crucial to successful treatment of HIV/AIDS. PUBLIC HEALTH RELEVANCE: Hearing impairment is associated with a decreased economic productivity, decreased quality of life, depression, reduced functional status and social isolation. Preserving communicational status and social interactions are crucial for productivity in the work force and personal well being. In addition, hearing impairment may prevent verbal communication with health care providers, interfere with understanding and compliance for medical recommendations and hinder adherence to medications crucial to successful treatment of HIV/AIDS.