Hearing Impairment in HIV/AIDS

描述（由申请人提供）：我们提出了一项为期5年的研究，以了解艾滋病毒感染的男性和女性听力障碍的患病率和病理生理学，包括长期抗逆转录病毒治疗的效果。我们计划检验这一假设，即感染艾滋病毒的个体经历听觉功能障碍，这种损害可能与疾病阶段和长期使用抗逆转录病毒治疗有关。我们将研究以下具体目标：1。评估HIV-1感染者与未感染者相比听力损害的患病率和类型，并确定年龄对这些人群听力功能的影响。我们假设感染HIV-1的个体会出现听觉功能障碍。HIV-1可能对耳蜗、第八神经或中枢听觉系统造成直接影响。我们预计，HIV-1感染患者可能有听力功能损害的早期生活相比，未感染的控制。2.确定HIV-1疾病分期对HIV-1感染者听力损害的影响。我们假设听力障碍在HIV-1感染者中的发病率在HIV疾病的晚期比在疾病的早期更高。我们预计，没有病毒学抑制的有症状的HIV-1感染者的听觉功能比持续病毒学控制的患者更差。3.确定抗逆转录病毒药物对听力功能的影响。我们假设长期使用抗逆转录病毒药物可能通过线粒体毒性和氧化过程的变化影响听力，这在某些方面可能与糖尿病对听觉系统的负面影响相似。一般来说，听力障碍与经济生产力下降、生活质量下降、抑郁、功能状态下降和社会孤立有关。保持沟通状态和社会互动对于工作队伍的生产力和个人福祉至关重要。此外，听力障碍可能妨碍与保健提供者的口头交流，干扰对医疗建议的理解和遵守，并妨碍坚持对成功治疗艾滋病毒/艾滋病至关重要的药物治疗。

DESCRIPTION (provided by applicant): We are proposing a 5-year study to understand the prevalence and pathophysiology of hearing impairment in HIV-infected men and women, including the effect of long-term antiretroviral therapy. We plan to examine the hypothesis that individuals infected with HIV experience auditory dysfunction and that this impairment may be associated with disease stage and long- term use of antiretroviral therapy. We will examine the following specific aims: 1. Assess the prevalence and types of hearing impairment in individuals infected with HIV-1 compared to uninfected controls and define the effects of aging on auditory function in these groups. We hypothesize that individuals infected with HIV-1 will experience auditory dysfunction. HIV-1 may cause a direct effect on the cochlea, eight nerve or central auditory system. We anticipate that HIV-1 infected patients may have impairment of auditory function earlier in life compared to uninfected controls. 2. Determine the influence of HIV-1 disease stage on auditory impairment in HIV-1 infected individuals. We hypothesize that hearing impairment will be more prevalent among HIV-1 infected individuals at advanced stages of HIV disease compared to individuals at earlier stages of the disease. We expect that individuals with symptomatic HIV-1 infection without virologic suppression will have worse auditory function than patients with sustained virologic control. 3. Determine the influence of antiretroviral medications on hearing function. We hypothesize that long-term use of antiretroviral medications affects hearing, possibly through mitochondrial toxicity and changes in the oxidative process, which may be similar, in some ways, to the negative effects of diabetes on the auditory system. In general, hearing impairment is associated with a decreased economic productivity, decreased quality of life, depression, reduced functional status and social isolation. Preserving communicational status and social interactions are crucial for productivity in the work force and personal well being. In addition, hearing impairment may prevent verbal communication with health care providers, interfere with understanding and compliance for medical recommendations and hinder adherence to medications crucial to successful treatment of HIV/AIDS.