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The Gas-Gangrene Causing Alpha-Toxin: Membrane Interaction and Toxicity

气性坏疽引起α-毒素：膜相互作用和毒性

基本信息

批准号：
G0700051/1
负责人：
David Moss
金额：
$ 64.01万
依托单位：
Birkbeck, University of London
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2007
资助国家：
英国
起止时间：
2007 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=G0700051%2F1
关键词：
Gas Gangrene Causing Alpha Toxin

项目摘要

As is frequently documented in the press, people are getting fatter all the time. In fact, by 2010 one in three of us will be clinically obese. Being overweight carries with it a range of health risks, including an increased likelyhood of developing type II diabetes. Diabetes, in turn, has a number of complications, including increased susceptibility to gengrene of the legs and feet. Gangrene is treated by the amputation of the infected leg, while if left untreated it is invariably fatal. This project aims to increase our understanding of what happens in our bodies once we have gangrene, and thus to increase the effectiveness of the treatment. Gas-gangrene is caused predominantly by a single toxin released by a bacterium that has infected an injury. This toxin attachs to and attacks human or animal cell walls. The result of this attack is the release of certain signals that cause changes in the limb and the rest of your body. We are going to study the interaction between the toxin and human cell walls by using light-emitting markers attached to the toxin or the cell wall and by examining the molecular structure of the toxin.We will identify which parts of the toxin make it interact strongly with cell walls. And, conversely, what features of the cell wall allow the toxin to attach to it. We will find out how we can change the behaviour of the toxin by changing the features of the cell wall and/or the toxin. This will allow us to devise strategies for mitagating the effects of the toxin in real cases.

正如媒体经常报道的那样，人们一直在变胖。事实上，到2010年，三分之一的人将被诊断为肥胖。超重会带来一系列健康风险，包括患II型糖尿病的可能性增加。反过来，糖尿病有许多并发症，包括对腿和脚基因的易感性增加。坏疽的治疗方法是截肢受感染的腿，但如果不及时治疗，它总是致命的。这个项目旨在提高我们对坏疽发生后身体状况的了解，从而提高治疗的有效性。气性坏疽主要是由感染伤口的细菌释放的一种毒素引起的。这种毒素会攻击人类或动物的细胞壁。这种攻击的结果是释放某些信号，导致肢体和身体其他部位发生变化。我们将利用附着在毒素或细胞壁上的发光标记，以及检查毒素的分子结构，来研究毒素与人体细胞壁之间的相互作用。我们将确定毒素的哪些部分使其与细胞壁产生强烈的相互作用。反过来说，细胞壁的哪些特征允许毒素附着在细胞壁上。我们将发现如何通过改变细胞壁和/或毒素的特征来改变毒素的行为。这将使我们能够制定策略，在实际情况下减轻毒素的影响。