Studies into the physiological reactions of myeloperoxidase (MPO) within the neutrophil phagocytic vacuole

中性粒细胞吞噬泡内髓过氧化物酶（MPO）生理反应的研究

• 批准号: G0700050/1
• 负责人: Tony Segal
• 金额: $ 43.02万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0700050%2F1
• 关键词: Studies; into; physiological; reactions; myeloperoxidase

Bacterial and fungal infections are a major cause of human and animal morbidity and mortality. If we understand the way in which the body normally deals with these infections we might be able to enhance these mechanisms, particularly important as antibiotic resistant microbes are emerging in increasing numbers. In addition, as the systems that are toxic to microbes can also damage normal tissues, this understanding can also be used to limit damaging inflammatory diseases such as arthritis. The most important cells involved in protecting the body against these infection are the neutrophils, the most numerous of the white blood cells. A key question is whether the enzyme myeloperoxidase acts to generate a toxic molecule, hypochlorous acid which is present in bleach, or to remove hydrogen peroxide from within the leukocyte. We will combine our expertise in different scientific disciplines to answer this fundamental question.

细菌和真菌感染是人类和动物发病和死亡的主要原因。如果我们了解身体通常处理这些感染的方式，我们也许能够增强这些机制，这在抗生素耐药微生物数量不断增加的情况下尤其重要。此外，由于对微生物有毒的系统也会损害正常组织，这种认识也可用于限制关节炎等破坏性炎症性疾病。保护身体免受这些感染的最重要的细胞是中性粒细胞，它是白细胞中数量最多的。一个关键问题是髓过氧化物酶是否会产生有毒分子（漂白剂中存在的次氯酸）或去除白细胞内的过氧化氢。我们将结合不同科学学科的专业知识来回答这个基本问题。