Characterisation of norovirus replication complex formation

诺如病毒复制复合物形成的表征

• 批准号: G0700109/1
• 负责人: Ian Goodfellow
• 金额: $ 46.16万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0700109%2F1
• 关键词: Characterisation; norovirus; replication; complex; formation

Members of the calicivirus family are responsible for important diseases of man and animals; noroviruses cause gastroenteritis or projectile vomiting in humans and outbreaks are often seen in hospitals, cruise ships and in military camps. We currently know very little with regards to how these viruses interact with the host cell and how this leads to the production of new virus particles. When noroviruses infect a host cell they have many effects that can alter the normal processes occurring within the host cell. One such effect is to generate replication ?factories? within the host cell where the viral genome is replicated. In order to better understand this important family of viruses, we now aim to characterise how these replication ?factories? are generated to identify methods of controlling outbreaks of these important viruses.

杯状病毒家族的成员对人类和动物的重要疾病负有责任；诺如病毒引起人类肠胃炎或抛射性呕吐，经常在医院、游轮和军营中爆发。我们目前对这些病毒如何与宿主细胞相互作用以及这如何导致新病毒颗粒的产生知之甚少。当诺如病毒感染宿主细胞时，它们会产生许多影响，可以改变宿主细胞内发生的正常过程。其中一种效果是生成复制工厂。在病毒基因组复制的宿主细胞内。为了更好地理解这一重要的病毒家族，我们现在的目标是描述这些复制工厂是如何为确定控制这些重要病毒爆发的方法而生成的。