Characterisation of norovirus replication complex formation

杯状病毒家族的成员负责人和动物的重要疾病;诺如病毒在人类中引起胃肠炎或喷射性呕吐，并且在医院，游轮和军营中经常看到爆发。我们目前对这些病毒如何与宿主细胞相互作用以及如何导致新病毒颗粒的产生知之甚少。当诺如病毒感染宿主细胞时，它们具有许多可以改变宿主细胞内发生的正常过程的作用。一个这样的效果是产生复制？工厂？在病毒基因组复制的宿主细胞内。为了更好地了解这个重要的病毒家族，我们现在的目标是研究这些病毒是如何复制的？工厂？以确定控制这些重要病毒爆发的方法。

Members of the calicivirus family are responsible for important diseases of man and animals; noroviruses cause gastroenteritis or projectile vomiting in humans and outbreaks are often seen in hospitals, cruise ships and in military camps. We currently know very little with regards to how these viruses interact with the host cell and how this leads to the production of new virus particles. When noroviruses infect a host cell they have many effects that can alter the normal processes occurring within the host cell. One such effect is to generate replication ?factories? within the host cell where the viral genome is replicated. In order to better understand this important family of viruses, we now aim to characterise how these replication ?factories? are generated to identify methods of controlling outbreaks of these important viruses.