The role of endosomal sorting proteins in HSV-1 assembly

内体分选蛋白在 HSV-1 组装中的作用

• 批准号: G0700129/1
• 负责人: Colin Crump
• 金额: $ 49.82万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0700129%2F1
• 关键词: role; endosomal; sorting; proteins; HSV

The herpesviruses are an important group of pathogens that infect humans and cause several medical problems including cold sores, shingles and glandular fever. Herpesviruses can also increase the risk of certain types of cancer, and can cause life-threatening conditions in immune-suppressed people, such as transplant patients. To be able to treat and control infections by these viruses, it is crucial that we understanding how these viruses infect us, how they produce new copies of themselves, and how they spread to new people. The research being proposed will use cell culture models to study the way in which herpesviruses control our cells own machinery in order to form new copies of the virus. Overall, the information gained from this research will give a greater understanding of how this important family of viruses can infect and replicate in our cells. Such information will hopefully identify new targets that could be inhibited by drugs to combat these viruses and the many diseases caused by them.

疱疹病毒是一组重要的病原体，感染人类，并导致几个医疗问题，包括唇疱疹，带状疱疹和腺热。疱疹病毒还可以增加某些类型癌症的风险，并可能导致免疫抑制人群（如移植患者）的生命威胁。为了能够治疗和控制这些病毒的感染，我们必须了解这些病毒是如何感染我们的，它们是如何产生新的自身拷贝的，以及它们是如何传播给新的人的。正在进行的研究将使用细胞培养模型来研究疱疹病毒控制我们细胞自身机制的方式，以形成病毒的新拷贝。总的来说，从这项研究中获得的信息将使我们更好地了解这个重要的病毒家族如何在我们的细胞中感染和复制。这些信息将有望确定新的目标，这些目标可以被药物抑制，以对抗这些病毒及其引起的许多疾病。