Role of Rho-family GTP-binding proteins in mammalian phagocytosis -a siRNA approach

Rho 家族 GTP 结合蛋白在哺乳动物吞噬作用中的作用 - siRNA 方法

• 批准号: G0700154/1
• 负责人: Emmanuelle Caron
• 金额: $ 43.37万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0700154%2F1
• 关键词: Role; Rho; family; GTP; binding

It is essential for an organism to get rid of dead cells and invading microorganisms. Specialized cells of the immune system, called macrophages, are particularly equipped for clearance of particulate material, a process referred to as phagocytosis. Anomalies in recognition or uptake result in inflammatory diseases and life-threatening infections. We need to better understand the fundamental mechanisms of phagocytosis to help design new drugs for patients suffering from these diseases. To do so, our research will focus on a particular class of molecules that control phagocytosis. We will determine which of them control uptake of different types of particles, and how they are regulated to do so. Thereby, it will later be possible to design drugs that block the adverse effects of phagocytosis, whilst maintaining of even boosting (where necessary) the beneficial sides of this fundamental physiological process.

对于生物体来说，清除死亡细胞和入侵的微生物是必不可少的。免疫系统的特殊细胞，称为巨噬细胞，专门用于清除颗粒物质，这一过程被称为吞噬作用。识别或摄取的异常会导致炎症性疾病和危及生命的感染。我们需要更好地了解吞噬作用的基本机制，以帮助为患有这些疾病的患者设计新药。为此，我们的研究将集中在控制吞噬作用的一类特定分子上。我们将确定它们中的哪些控制不同类型颗粒的摄取，以及它们如何被监管来做到这一点。因此，以后将有可能设计出阻止吞噬作用的不利影响的药物，同时保持甚至增强(在必要时)这一基本生理过程的有益方面。