CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH

本分项目是CTSA供资的估计百分比，即 被用于广泛的研究领域(艾滋病研究、儿科研究或 临床试验)。列出的总成本仅是对CTSA金额的估计 用于这一研究领域的基础设施，而不是由 授予子项目或子项目工作人员的NCRR补助金。 芝加哥大学CTSA计划的最终目标是培训大学、我们的合作机构和我们社区的科学家和医疗保健提供者，以确定疾病或疾病易感性在任何个体患者中的分子基础；开发、测试、实施并向我们社区的居民提供针对这些个体基础的个性化治疗；并以严格、有效、高效、道德和尊重我们社区的需求和价值观的方式开展这项工作。在与阿贡国家实验室、伊利诺伊理工学院和两个大型医疗保健组织的强大联盟中，我们将采取三个大胆的新步骤，将改变我们机构和社区的临床和转化性研究：1)创建转化医学研究所，这是一个新的大学范围的结构，以收集、整合和传播促进和支持多学科转化性研究合作所需的智力、组织和资源基础设施；2)与新的加州大学城市健康倡议的协同研究互动，通过与社区利益攸关方的合作，旨在改善社区医疗保健的可获得性和质量，在整个社区建立健康素养和信任，加强了解并响应社区需求的转换研究计划，从而减少健康差距；以及3)建立新的临床和转换科学学术委员会，并设立多个新颖的培训计划，以鼓励和发展临床和转换研究的职业生涯，面向高中生，通过大学教师和整个转换研究范围。我们致力于CTSA调查的联盟将采用系统医学的方法来利用他们在社会科学、遗传医学和综合疗法方面的特殊专业知识。这一团队和这些变革性的创新将使芝加哥大学CTSA能够培养下一代临床和转化型研究人员，以实现我们的愿景，即广泛可用、有效和个性化的疗法，这些疗法在社区实践中得到日常应用，从而减少不同成人和儿科人群的健康差距。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. The ultimate goals of the University of Chicago CTSA program are to train scientists and health care providers at the University, our partner institutions, and our Community to determine the molecular underpinnings of disease or disease predisposition in any individual patient; to develop, test, implement, and make readily available to residents in our Community personalized therapies directed toward those individual underpinnings; and to do this in a way that is rigorous, valid, efficient, ethical, and respectful of our Community's needs and values. In a robust alliance with Argonne National Laboratory, the Illinois Institute of Technology, and two large healthcare organizations, we will undertake three bold new steps that will transform clinical and translational research at our institutions and in our Community: 1) Creation of an Institute for Translational Medicine, a new University-wide structure to collect, integrate, and disseminate the intellectual, organizational, and resource infrastructure needed to promote and support multidisciplinary translational research collaborations; 2) Synergistic research interaction with a new UC Urban Health Initiative which, through partnership with Community stakeholders, aims to improve Community health care access and quality, to build health literacy and trust throughout the Community, to enhance a translational research program informed by and responsive to the needs of the Community, and so to reduce health disparities; and 3) Establishment of a new academic Committee on Clinical and Translational Science and of multiple novel training programs to encourage and develop careers in clinical and translational research, intended for high school students through university faculty and across the entire translational research spectrum. Our consortium of dedicated CTSA investigators will employ a systems medicine approach to leverage their particular expertise in social science, genetic medicine, and integrative therapeutics. Together, this team and these transforming innovations will allow the University of Chicago CTSA to prepare the next generation of clinical and translational researchers to realize our vision of widely available, effective, and personalized therapies that find everyday application in Community practice and thereby reduce health disparities in diverse adult and pediatric populations.