TRANSLATIONAL RESEARCH AT THE UNIVERSITY OF CHICAGO

该子项目是对CTSA供资的百分比的估计， 用于广泛的研究领域（艾滋病研究，儿科研究，或 临床试验）。 列出的总成本仅为CTSA金额的估算 用于该研究领域的基础设施，而不是直接提供的资金 向子项目或子项目工作人员提供NCRR补助金。 芝加哥大学CTSA计划的最终目标是培训大学，我们的合作机构和我们的社区的科学家和医疗保健提供者，以确定任何个体患者的疾病或疾病易感性的分子基础;开发，测试，实施，并随时提供给我们社区的居民针对这些个体基础的个性化疗法;并以严谨、有效、高效、道德和尊重我们社区需求和价值观的方式做到这一点。在与阿贡国家实验室，伊利诺伊理工学院和两个大型医疗保健组织的强大联盟中，我们将采取三个大胆的新步骤，这将改变我们机构和社区的临床和转化研究：1）创建转化医学研究所，这是一个新的全校性结构，旨在收集，整合和传播知识，组织，以及促进和支持多学科转化研究合作所需的资源基础设施; 2）协同研究与新的UC城市健康倡议的互动，通过与社区利益相关者的伙伴关系，旨在改善社区卫生保健的获取和质量，在整个社区建立健康素养和信任，加强转化研究计划，了解并响应社区的需求，从而减少健康差距;以及3）建立一个新的临床和转化科学学术委员会和多个新颖的培训计划，以鼓励和发展临床和转化研究的职业生涯，旨在高中学生通过大学教师和整个翻译研究范围。我们的专门CTSA研究者联盟将采用系统医学方法，利用他们在社会科学，遗传医学和综合治疗方面的特殊专业知识。总之，这个团队和这些变革创新将使芝加哥CTSA大学准备下一代临床和转化研究人员，以实现我们广泛可用，有效和个性化的治疗，在社区实践中找到日常应用的愿景，从而减少不同成年人群的健康差距。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. The ultimate goals of the University of Chicago CTSA program are to train scientists and health care providers at the University, our partner institutions, and our Community to determine the molecular underpinnings of disease or disease predisposition in any individual patient; to develop, test, implement, and make readily available to residents in our Community personalized therapies directed toward those individual underpinnings; and to do this in a way that is rigorous, valid, efficient, ethical, and respectful of our Community's needs and values. In a robust alliance with Argonne National Laboratory, the Illinois Institute of Technology, and two large healthcare organizations, we will undertake three bold new steps that will transform clinical and translational research at our institutions and in our Community: 1) Creation of an Institute for Translational Medicine, a new University-wide structure to collect, integrate, and disseminate the intellectual, organizational, and resource infrastructure needed to promote and support multidisciplinary translational research collaborations; 2) Synergistic research interaction with a new UC Urban Health Initiative which, through partnership with Community stakeholders, aims to improve Community health care access and quality, to build health literacy and trust throughout the Community, to enhance a translational research program informed by and responsive to the needs of the Community, and so to reduce health disparities; and 3) Establishment of a new academic Committee on Clinical and Translational Science and of multiple novel training programs to encourage and develop careers in clinical and translational research, intended for high school students through university faculty and across the entire translational research spectrum. Our consortium of dedicated CTSA investigators will employ a systems medicine approach to leverage their particular expertise in social science, genetic medicine, and integrative therapeutics. Together, this team and these transforming innovations will allow the University of Chicago CTSA to prepare the next generation of clinical and translational researchers to realize our vision of widely available, effective, and personalized therapies that find everyday application in Community practice and thereby reduce health disparities in diverse adult populations.