Investigating aberrant neuronal calcium regulation by calpain in Alzheimer s Disease

研究阿尔茨海默病中钙蛋白酶对神经元钙的异常调节

• 批准号: G0700355/1
• 负责人: Wendy Noble
• 金额: $ 44.15万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0700355%2F1
• 关键词: Investigating; aberrant; neuronal; calcium; regulation

People who suffer from Alzheimer’s disease (AD) have severe memory loss and dementia. These symptoms are caused by the progressive and relentless death of nerve cells in the brain that we use for memory, recognition and most brain functions that give us our personality. My research is aimed at investigating why nerve cells die in AD because if we can prevent this cell death then we will have effective treatments for this devastating condition. I will focus on events that increase the amount of calcium inside nerve cells. Normally there is a balance between the amount of calcium entering and leaving nerve cells, but in AD this process is disrupted and excess calcium inside nerve cells causes them to die. My project will investigate the reasons for this calcium imbalance. I will also use animal models to test the effectiveness of drugs that should restore the calcium balance to determine whether they can prevent the nerve cell death that is characteristic of AD. This work may lead to a new strategy for treating AD which can be developed by the pharmaceutical industry and could result in a new generation of treatments for this devastating illness.

患有阿尔茨海默病（AD）的人有严重的记忆丧失和痴呆症。这些症状是由大脑中神经细胞的渐进和无情死亡引起的，我们用于记忆，识别和赋予我们个性的大多数大脑功能。我的研究旨在调查为什么神经细胞会在AD中死亡，因为如果我们能够阻止这种细胞死亡，那么我们将有有效的治疗方法来治疗这种毁灭性的疾病。我将集中讨论增加神经细胞内钙含量的事件。正常情况下，进入和离开神经细胞的钙量之间存在平衡，但在AD中，这一过程被破坏，神经细胞内过量的钙导致它们死亡。我的项目将调查这种钙不平衡的原因。我还将使用动物模型来测试应该恢复钙平衡的药物的有效性，以确定它们是否可以防止AD特征性的神经细胞死亡。这项工作可能会导致一种治疗AD的新策略，这种策略可以由制药行业开发，并可能导致这种毁灭性疾病的新一代治疗方法。