Characterisation of the LRRK2 protein kinase, mutated in inherited Parkinson s disease

遗传性帕金森病中突变的 LRRK2 蛋白激酶的特征

• 批准号: G0700656/1
• 负责人: Dario Alessi
• 金额: $ 32.38万
• 依托单位: University of Dundee
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0700656%2F1
• 关键词: Characterisation; LRRK2; protein; kinase; mutated

Parkinson?s disease is a serious degenerative brain disorder resulting in tremors and abnormally slow movements in patients. The disease has no cure and is a major cause of disability and early death worldwide. A recent breakthrough has lead to the discovery that mutations in a gene called LRRK2 can cause Parkinson?s disease in humans. The LRRK2 gene encodes for an enzyme. It is not known how the LRRK2 enzyme works in human brains and how its mutation causes Parkinson?s disease. The purpose of this application is to undertake studies that define how LRRK2 works in the brain. We also aim to learn how mutations in LRRK2 might cause Parkinson?s disease. Moreover, this research will provide knowledge and methodology to facilitate the development of new drugs that target the LRRK2 enzyme for the treatment of Parkinson?s disease ? and possibly dementias such as Alzheimer?s disease.

帕金森吗?S病是一种严重的退行性脑部疾病，患者会出现震颤和异常缓慢的运动。这种疾病无法治愈，是全世界残疾和早期死亡的主要原因。最近的一项突破发现，一种名为LRRK2的基因突变会导致帕金森病。人类的S疾病LRRK2基因编码一种酶。目前尚不清楚LRRK2酶是如何在人脑中起作用的，以及它的突变是如何导致帕金森病的。年代的疾病。这项申请的目的是进行研究，确定LRRK2如何在大脑中起作用。我们还旨在了解LRRK2突变如何导致帕金森？年代的疾病。此外，该研究将为开发靶向LRRK2酶治疗帕金森病的新药提供知识和方法。S疾病？可能还有老年痴呆症？年代的疾病。