Characterisation of the LRRK2 protein kinase, mutated in inherited Parkinson s disease

帕金森？帕金森氏病是一种严重的脑部退化性疾病，患者会出现震颤和异常缓慢的动作。这种疾病无法治愈，是全世界残疾和过早死亡的主要原因。最近的一项突破导致了一种名为LRRK2的基因突变会导致帕金森病的发现。的疾病在人类。LRRK2基因编码一种酶。目前尚不清楚LRRK2酶如何在人脑中工作，以及它的突变如何导致帕金森？的疾病。本申请的目的是进行研究，确定LRRK2如何在大脑中工作。我们还旨在了解LRRK2突变如何导致帕金森病？的疾病。此外，这项研究将提供知识和方法，以促进开发新的药物，靶向LRRK2酶治疗帕金森病？的疾病？可能还有老年痴呆症之类的的疾病。

Parkinson?s disease is a serious degenerative brain disorder resulting in tremors and abnormally slow movements in patients. The disease has no cure and is a major cause of disability and early death worldwide. A recent breakthrough has lead to the discovery that mutations in a gene called LRRK2 can cause Parkinson?s disease in humans. The LRRK2 gene encodes for an enzyme. It is not known how the LRRK2 enzyme works in human brains and how its mutation causes Parkinson?s disease. The purpose of this application is to undertake studies that define how LRRK2 works in the brain. We also aim to learn how mutations in LRRK2 might cause Parkinson?s disease. Moreover, this research will provide knowledge and methodology to facilitate the development of new drugs that target the LRRK2 enzyme for the treatment of Parkinson?s disease ? and possibly dementias such as Alzheimer?s disease.