Understanding Signalling Pathways Mutated in Inherited Disorders

了解遗传性疾病中突变的信号通路

基本信息

  • 批准号:
    MC_UU_00018/1
  • 负责人:
  • 金额:
    $ 559.88万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Intramural
  • 财政年份:
    2018
  • 资助国家:
    英国
  • 起止时间:
    2018 至 无数据
  • 项目状态:
    已结题

项目摘要

My laboratory focuses on unravelling the roles played by an important class of enzymes that are implicated in human disease, that control a biological process known as “protein phosphorylation”. Many diseases including Parkinson’s disease, cancer and high blood pressure, are caused by alterations in specific pathways that regulate protein phosphorylation. My research programme will be based on deciphering the molecular details of protein phosphorylation pathways that are associated with Parkinson’s Disease (LRRK2), cancer (SGK3 pathway) and hypertension (WNK pathway). The overarching goal of our research is to discover how disruptions in enzymes that regulate phosphorylation are linked to human disease. We aim to harness this information and work with clinicians as well as pharmaceutical companies to develop improved strategies to better treat and diagnose malady.
我的实验室专注于解开一类与人类疾病有关的重要酶所扮演的角色,这些酶控制着一种被称为“蛋白质磷酸化”的生物过程。许多疾病,包括帕金森氏症、癌症和高血压,都是由调节蛋白质磷酸化的特定途径的改变引起的。我的研究计划将基于破译与帕金森氏病(LRRK2)、癌症(SGK3途径)和高血压(WNK途径)相关的蛋白质磷酸化途径的分子细节。我们研究的首要目标是发现调节磷酸化的酶的干扰是如何与人类疾病有关的。我们的目标是利用这些信息,并与临床医生和制药公司合作,制定改进的战略,以更好地治疗和诊断疾病。

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The New p.F1700L LRRK2 Variant Causes Parkinson's Disease by Extensively Increasing Kinase Activity.
新的 p.F1700L LRRK2 变体通过大幅增加激酶活性导致帕金森病。
Development of BromoTag: A "Bump-and-Hole"-PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins.
  • DOI:
    10.1021/acs.jmedchem.1c01532
  • 发表时间:
    2021-10-28
  • 期刊:
  • 影响因子:
    7.3
  • 作者:
    Bond AG;Craigon C;Chan KH;Testa A;Karapetsas A;Fasimoye R;Macartney T;Blow JJ;Alessi DR;Ciulli A
  • 通讯作者:
    Ciulli A
Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase.
  • DOI:
    10.1042/bcj20220019
  • 发表时间:
    2022-03-18
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Staining of cells with GolgiTracker for Golgi flow cytometry analysis v1
使用 GolgiTracker 对细胞进行染色,进行高尔基流式细胞术分析 v1
  • DOI:
    10.17504/protocols.io.e6nvwk1d2vmk/v1
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Bagnoli E
  • 通讯作者:
    Bagnoli E
Disruption of the with no lysine kinase-STE20-proline alanine-rich kinase pathway reduces the hypertension induced by angiotensin II.
  • DOI:
    10.1097/hjh.0000000000001554
  • 发表时间:
    2018-03
  • 期刊:
  • 影响因子:
    4.9
  • 作者:
    Cervantes-Perez LG;Castaneda-Bueno M;Jimenez JV;Vazquez N;Rojas-Vega L;Alessi DR;Bobadilla NA;Gamba G
  • 通讯作者:
    Gamba G
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Dario Alessi其他文献

DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides.
DAPP1:磷酸酪氨酸和 3-磷酸肌醇的双重接头。
  • DOI:
    10.1042/bj3420007
  • 发表时间:
    1999
  • 期刊:
  • 影响因子:
    0
  • 作者:
    S. Dowler;Richard A. Currie;C. Downes;Dario Alessi
  • 通讯作者:
    Dario Alessi
Redox-driven photoselective self-assembly
氧化还原驱动的光选择性自组装
  • DOI:
    10.1038/s41467-025-58890-4
  • 发表时间:
    2025-05-09
  • 期刊:
  • 影响因子:
    15.700
  • 作者:
    Dario Alessi;Luca Morgan;Elisa Pelorosso;Claudia Graiff;Piermaria Pinter;Alessandro Aliprandi
  • 通讯作者:
    Alessandro Aliprandi

Dario Alessi的其他文献

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{{ truncateString('Dario Alessi', 18)}}的其他基金

MRC Climate Crisis Network
MRC 气候危机网络
  • 批准号:
    MC_PC_21020
  • 财政年份:
    2022
  • 资助金额:
    $ 559.88万
  • 项目类别:
    Intramural
Stratification of MRC funded scientific technologies and reagents for rapid and simple dissemination to the wider scientific community
对 MRC 资助的科学技术和试剂进行分层,以便快速、简单地向更广泛的科学界传播
  • 批准号:
    MC_PC_20034
  • 财政年份:
    2021
  • 资助金额:
    $ 559.88万
  • 项目类别:
    Intramural
Towards a unifying theory of Parkinson's disease: Investigation of the biochemical and genetic role of Rab GTPases
迈向帕金森病的统一理论:Rab GTPases 生化和遗传作用的研究
  • 批准号:
    MR/P00704X/1
  • 财政年份:
    2016
  • 资助金额:
    $ 559.88万
  • 项目类别:
    Research Grant
BBSRC Industrial CASE Partnership Grant
BBSRC 工业案例合作伙伴资助
  • 批准号:
    BB/I532253/1
  • 财政年份:
    2010
  • 资助金额:
    $ 559.88万
  • 项目类别:
    Training Grant
Exploitation of mouse models to validate protein kinases as drug targets
利用小鼠模型验证蛋白激酶作为药物靶点
  • 批准号:
    MC_EX_G0802532
  • 财政年份:
    2009
  • 资助金额:
    $ 559.88万
  • 项目类别:
    Research Grant
Characterisation of the LRRK2 protein kinase, mutated in inherited Parkinson s disease
遗传性帕金森病中突变的 LRRK2 蛋白激酶的特征
  • 批准号:
    G0700656/1
  • 财政年份:
    2008
  • 资助金额:
    $ 559.88万
  • 项目类别:
    Research Grant

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