Evolutionary significance and function of influenza A virus genome packaging signals

甲型流感病毒基因组包装信号的进化意义和功能

• 批准号: G0700815/1
• 负责人: Paul Digard
• 金额: $ 76.71万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0700815%2F1
• 关键词: Evolutionary; significance; function; influenza; virus

The threat of an influenza pandemic is ever present and the prospect of the current strain of bird flu achieving pandemic status is truly alarming. Influenza viruses can evolve rapidly by swapping genes amongst strains of viruses from different hosts. However, key aspects of the processes that govern this ?pick and mix? process are not understood. This grant aims at clarifying the molecular details of influenza evolution with the ultimate aim of being able to predict which combinations of viruses might be more dangerous.

流感大流行的威胁一直存在，当前禽流感毒株达到大流行状态的前景确实令人担忧。流感病毒可以通过在来自不同宿主的病毒株之间交换基因而迅速进化。然而，控制这一过程的关键方面是什么？pick and mix？过程不被理解。这项资助旨在澄清流感演变的分子细节，最终目的是能够预测哪些病毒组合可能更危险。