Pathways of action of the potent anorexigenic gut hormones pancreatic polypeptide and peptide YY.

有效的厌食肠道激素胰多肽和肽 YY 的作用途径。

• 批准号: G0701371/1
• 负责人: Victoria Salem
• 金额: $ 27.96万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0701371%2F1
• 关键词: Pathways; action; potent; anorexigenic; gut

Obesity is the major cause of early death in the UK, accounting for an estimated 600 prematuredeaths per week. As yet there are no effective treatments and the factors which regulate appetiteand body weight are largely unknown.Pancreatic polypeptide (PP) and Peptide YY (PYY) are hormones released from the gut inresponse to food intake. Recently they have both been shown to act in the brain to reduceappetite, and can therefore be thought of as part of the body‘s mechanism of feeling full after ameal. Infusions of these hormones into humans have consistently shown powerful and sustainedeffects in lowering food intake. Exciting work is already underway to develop analogues that canbe effectively administered as weight-loss drugs.There remains a large gap in our understanding of how PP and PYY exert their appetite-reducingeffects in the brain. Although their structure and effects are very similar, we know that they eachhave a strong preference for different receptors and therefore stimulate different appetite signals inthe brain. By comparing and contrasting the effects of PP and PYY, I will contribute to our overallunderstanding of the pathways that control of food intake.

在英国，肥胖是导致过早死亡的主要原因，据估计每周有600人过早死亡。目前还没有有效的治疗方法，调节食欲和体重的因素在很大程度上是未知的。胰多肽（PP）和肽YY（PYY）是消化道对食物摄入做出反应时释放的激素。最近，它们都被证明在大脑中起作用以减少食欲，因此可以被认为是饭后感觉饱的身体机制的一部分。将这些激素注入人体，在降低食物摄入量方面一直显示出强大和持续的效果。令人兴奋的工作已经在进行中，以开发类似物作为有效的减肥药物。我们对PP和PYY如何在大脑中发挥其降低食欲的作用的理解仍然存在很大的差距。虽然它们的结构和作用非常相似，但我们知道它们各自对不同的受体有强烈的偏好，因此在大脑中激发不同的食欲信号。通过比较和对比PP和PYY的影响，我将有助于我们全面了解控制食物摄入的途径。