Polycyclic Aromatic Hydrocarbons And Male Reproductive Health

多环芳烃与男性生殖健康

• 批准号: 7922119
• 负责人: Hueiwang Anna Cook Jeng
• 金额: $ 7.5万
• 依托单位: OLD DOMINION UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7922119
• 关键词: Polycyclic; Aromatic; Hydrocarbons; Male; Reproductive

DESCRIPTION (provided by applicant): Polycyclic Aromatic Hydrocarbons and Male Reproductive Health Despite heightened concerns over reported declines in sperm quality; a lack of epidemiologic data exists regarding a link to job-related environmental exposure. Increasing evidence, however, from animal studies has shown that polycyclic aromatic hydrocarbons (PAHs) contribute to male rat reproductive system dysfunction. At the same time, PAH exposure as a contributing factor to male reproductive health in humans is still inconclusive. The long term goals of the project are: i) to develop field data collection methods to monitor human occupational exposure to PAHs; ii) to evaluate the reproductive altering potential of the exposure; iii) to evaluate the influence of genetic susceptibility to PAH exposure; and ultimately iv) to distribute the information to protect workers' health and safety. We hypothesize that PAH exposure contributes to decreased sperm quality of coke-oven workers, especially those with susceptible gene polymorphisms. The research component describes a cross-sectional study to characterize coke-oven workers' sperm quality, quantify PAH biomarker levels, and detect allelic variants in CYP1A1 and GSTM1 genes. Urine samples will be collected for determining PAH internal exposure levels. Baseline serum samples will be collected for genotype analysis of CYP1A1 and GSTM1 allelic variants. Semen will be collected to assess sperm quality and DNA integrity, and PAH-DNA adducts. Features of this design include efficient control for confounding factors, accurate exposure ascertainment, sufficient power to detect exposure related changes in reproductive indicators; and design efficiency to evaluate polymorphic influence on PAH metabolization. Research results may prompt reforms in workplace practices and policies to protect the reproductive health of workers exposed to PAHs. Public Health Relevance: The study aims to assess individual coke-oven workers' susceptibility to PAHs from occupational exposure, which may cause decreased sperm quality.

描述（由申请人提供）： 多环芳烃与男性生殖健康尽管人们对精子质量下降的报道表示高度关注，但缺乏与工作相关的环境暴露相关的流行病学数据。然而，越来越多的动物研究证据表明，多环芳烃（PAHs）有助于雄性大鼠生殖系统功能障碍。与此同时，多环芳烃暴露作为人类男性生殖健康的一个促成因素仍然没有定论。该项目的长期目标是：i）开发现场数据收集方法，以监测人类职业暴露于多环芳烃; ii）评估暴露的生殖改变潜力; iii）评估遗传易感性对多环芳烃暴露的影响;以及最终iv）分发信息，以保护工人的健康和安全。我们推测，多环芳烃暴露有助于降低焦炉工人的精子质量，特别是那些易感基因多态性。研究部分描述了一项横断面研究，以表征焦炉工人的精子质量，量化PAH生物标志物水平，并检测CYP 1A 1和GSTM 1基因的等位基因变异。将采集尿液样本用于测定PAH内部暴露水平。将采集基线血清样本用于CYP 1A 1和GSTM 1等位基因变体的基因型分析。将采集精液以评估精子质量和DNA完整性以及PAH-DNA加合物。该设计的特点包括有效控制混杂因素，准确的暴露确定，足够的权力，以检测暴露相关的生殖指标的变化;和设计效率，以评估多态性对PAH代谢的影响。研究结果可能会促进工作场所实践和政策的改革，以保护暴露于多环芳烃的工人的生殖健康。 公共卫生相关性：本研究旨在评估个体焦炉工人对职业暴露的多环芳烃的易感性，这可能会导致精子质量下降。

项目成果

Biomonitoring of polycyclic aromatic hydrocarbons from coke oven emissions and reproductive toxicity in nonsmoking workers.

• DOI: 10.1016/j.jhazmat.2012.11.008
• 发表时间: 2013-01
• 期刊: Journal of hazardous materials
• 影响因子: 13.6
• 作者: H. Jeng;C. Pan;Wen-Yi Lin;Ming-Tsang Wu;Steven L. Taylor;G. Chang-Chien;Guodong Zhou;N. Diawara