Keratinocyte growth factor as a novel treatment in an in vivo human endotoxaemic model of lung injury

角质形成细胞生长因子作为人体内毒血症肺损伤模型的新型治疗方法

• 批准号: G0701690/1
• 负责人: Danny McAuley
• 金额: $ 31.43万
• 依托单位: Queen's University Belfast
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0701690%2F1
• 关键词: Keratinocyte; growth; factor; novel; treatment

In many severe illnesses, such as pneumonia or following a road traffic accident, people develop acute lung problems. For reasons that are unclear, their lungs fail and fill with water making breathing difficult and they require support in an intensive care unit. This is termed ?acute lung injury? (ALI). There is no effective treatment for ALI.The reason the lung fails involves damage to the delicate lining of cells that allow oxygen to pass into the body. This lining is called the alveolar epithelium. A protein called keratinocyte growth factor (KGF) improves lung repair by increasing the number of lining cells and helping them move to damaged parts of the lung. Humans produce KGF, however, patients who have ALI do not have enough and repair is inadequate.This study will investigate if additional KGF helps lung repair in an established clinical model of ALI.If effective, results of this study will lead to a clinical trial of this novel therapy in the prevention and treatment of ALI. This project will also provide new information about mechanisms in the development of ALI which could lead to new therapeutic targets.

在许多严重的疾病中，如肺炎或道路交通事故，人们会出现急性肺部问题。由于尚不清楚的原因，他们的肺衰竭，充满水，使呼吸困难，他们需要在重症监护室的支持。这被称为？急性肺损伤（ALI）。目前还没有有效的治疗方法。肺衰竭的原因涉及到允许氧气进入体内的细胞的脆弱内层的损伤。这一层叫做肺泡上皮。一种称为角质细胞生长因子（KGF）的蛋白质通过增加衬里细胞的数量并帮助它们移动到肺部受损部位来改善肺部修复。人类产生KGF，然而，患有ALI的患者没有足够的KGF并且修复不充分。本研究将在已建立的ALI临床模型中调查额外的KGF是否有助于肺修复。如果有效，本研究的结果将导致这种新疗法在预防和治疗ALI中的临床试验。该项目还将提供有关ALI发展机制的新信息，从而可能导致新的治疗靶点。