Intergenerational Determinants of Youth Smoking Trajectories

描述（由申请人提供）：本研究的长期目标是了解烟草相关健康风险的代际传递。它侧重于母婴暴露于怀孕期间母亲吸烟（SDP）的作用。有四个具体目标：1)描述青少年吸烟轨迹；2a)评估SDP与青少年吸烟轨迹之间直接关系的强度；2b)评估在儿童和青少年时期由后代的行为问题或母亲继续吸烟引起的间接影响的强度；3)将SDP对青少年吸烟轨迹的影响从其他个人、同伴和家庭吸烟决定因素中分离出来。该研究开发了一个综合的寿命-生命过程框架，提供了关于将母亲的吸烟行为与其子女的吸烟行为联系起来的社会和生物学机制的四种假设。方法方法扩展和评估以前文献的发现。数据来自1979年全国青年纵向调查（NLSY79）和NLSY79的儿童和年轻人（NLSY79- cya）。NLSY79和NLSY79- cya共同构成了一项具有人口代表性的两年一次的调查，调查对象是1986-2004年18年间的母亲及其所生的所有儿童。这些调查提供了丰富的代际数据，涉及孕产妇和青少年药物使用、儿童认知和行为发展，以及儿童、家庭、同伴和邻里层面烟草使用的社会和生物学决定因素。我们采用一种自回归的潜在轨迹方法，使我们能够检查在不同年龄测量的决定因素之间的因果关系，同时也使用潜在变量方法来纠正通过社会和发展途径对中介的低估。

DESCRIPTION (provided by applicant): The long-term objective of this study is to understand intergenerational transmission of tobacco-related health risks. It focuses on the role of maternal-child exposure to maternal smoking during pregnancy (SDP). There are four specific aims: 1) characterize youth smoking trajectories; 2a) evaluate the strength of direct relationships between SDP and youth smoking trajectories; 2b) evaluate the strength of indirect influences that entail mediation during childhood and adolescence by either the offspring's behavior problems or the mother's continued smoking; 3) disentangle the influence of SDP on youth smoking trajectories from other individual, peer, and family determinants of smoking. The study develops an integrated lifespan-life course framework informing four hypotheses about the social and biological mechanisms linking mothers' smoking behavior with that of their children. The methodological approach extends and evaluates findings from previous literature. Data come from the National Longitudinal Survey of Youth 1979 (NLSY79) and the Children & Young Adults of the NLSY79 (NLSY79-CYA). Together the NLSY79 and NLSY79-CYA comprise a population-representative, biennial survey of mothers and all children born to them over an 18 year period from 1986-2004. These surveys offer rich, intergenerational data on maternal and youth substance use, child cognitive and behavioral development, and the social and biological determinants of tobacco-use at the child, family, peer and neighborhood level. We employ an autoregressive latent trajectory approach that allows us to examine causal relationships among determinants measured at different ages, while also using latent variable methods to correct for the underestimation of mediation through social and developmental pathways. PUBLIC HEALTH RELEVANCE: This study examines how intergenerational pathways in early life, childhood and adolescence shape tobacco related determinants of the health and social wellbeing of maturing adolescents and young adults.