FASEB Summer Conference on Protein Phosphatases

描述(申请人提供)：蛋白质磷酸化的翻译后修饰可能是最常见的生物调节机制，而蛋白质磷酸酶是控制这一过程的关键和复杂的酶。这项申请请求继续支持第十届和随后的FASE B蛋白质磷酸酶夏季研究会议，也是对蛋白质酪氨酸磷酸酶发现20周年的认可。这次两年一度的会议是北美关于这一主题的主要会议，为实验生物学家提供了一个亲密的环境，让他们探索和讨论当前蛋白质磷酸酶研究的前沿领域及其在调节生命中的重要作用。会议将重点介绍磷酸酶在癌症、干细胞、糖尿病和代谢紊乱中的作用的主要进展。我们的会议将包括关于癌症、糖尿病、神经疾病、传染病和发育异常的会议，所有这些领域的蛋白磷酸酶都发挥着关键作用。 会议的具体目标是： (1)介绍蛋白磷酸酶的结构、调控和功能的最新研究进展。将特别注意这些酶的不同的生理和病理生理学作用，通过在哺乳动物和其他真核系统中使用不同的方法来阐明。 (二)分别利用开场讲座和主旨讲座突出该领域的重大成就和新兴机遇。 (3)鼓励招聘和培养该领域的新科学家和青年科学家，特别是初级教员、妇女和代表性不足的少数群体，从提交的摘要中挑选大量发言者，并邀请在该领域取得新进展的人提供意见。

DESCRIPTION (provided by applicant): Post-translational modification by protein phosphorylation is perhaps the most common biological regulatory mechanism, and protein phosphatases are key and complex enzymes that control this process. This application requests ongoing support for the Tenth and subsequent FASEB Summer Research Conferences on Protein Phosphatases, also recognizing the 20th anniversary of the identification of protein tyrosine phosphatases. This bi-annual meeting, the major North American meeting on this topic, provides an intimate environment for experimental biologists to explore and discuss cutting edge areas of current research on protein phosphatases and their important role in regulation of life. Major advances in the role of phosphatases in cancer, stem cells, diabetes, and metabolic disorders will be highlighted at the meeting. Our conference will include sessions on cancer, diabetes, neurological disorders, infectious diseases and developmental abnormalities, all areas where protein phosphatases play critical roles. The Specific Aims of the conference are: (1) To present the most current work on the structure, regulation and function of the protein phosphatases. Particular attention will be paid to the diverse physiological and pathophysiological roles of these enzymes, as elucidated by the use of diverse approaches in mammalian and other eukaryotic systems. (2) To highlight major achievements and emerging opportunities in the field through the use of Opening and Keynote Lectures, respectively. (3) To encourage the recruitment and development of new and young scientists in the field, especially junior faculty, women and under-represented minorities, by selecting a significant number of speakers from the submitted abstracts and inviting contributions from those making novel advances in the field.