What determines an individual's vulnerability to the harmful effects of cannabis?

是什么决定了个人对大麻有害影响的脆弱性？

• 批准号: G0800268/1
• 负责人: Helen Curran
• 金额: $ 74.69万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0800268%2F1
• 关键词: What; determines; individual; vulnerability; harmful

A young person who has ever used cannabis has a 40% increased risk of developing a psychotic disorder like schizophrenia; in those using heavily, the increased risk can be 200%. There are also rapidly growing numbers of young people now seeking treatment for cannabis addiction. The Times recently headlined that in England: ?500 cannabis smokers a week seek medical help? (January 11th, 2008). Further, the effects of cannabis on the brain raise concerns that young people who use this drug may under-achieve in education or work. What we don?t yet understand is why some individuals can use cannabis with few apparent harmful effects whereas others become mentally ill or addicted or have problems concentrating and remembering. In the first research of its kind, we recently discovered that two main constituents (THC and CBD) in the cannabis that young people smoke influence the psychotic-like effects they experience in everyday life. The proposed research builds on this finding and on our recent large-scale study with 244 young people assessing the effects of cannabis. It aims to determine which cannabis-related and which individual factors make some young people vulnerable to the harmful effects of the drug. The three main harms it addresses are psychotic-like symptoms, addiction and cognitive impairment. The first phase of the study will be naturalistic and involve 600 16-23 year olds who differ in their cannabis use. Some cannabis users will be selected for Phase 2 - a controlled, laboratory study of the effects of two main constituents of cannabis (THC and CBD) both alone and combined. In both Phases, the effects we will assess are psychotic-like, addiction-related and cognitive. We will also investigate young people?s beliefs and views about different strains of cannabis, such as skunk and sinsemilla. At the time of writing this proposal, the Government is waiting for findings of yet another review of the classification of cannabis. Whether or not this results in it being raised from Class C to B will have negligible impact on cannabis users.If we show that the harmful effects can be reduced if vulnerable youngsters choose strains with higher CBD content, or if they take CBD supplements, then this could lead to a new era of safer cannabis use. Importantly, it could significantly reduce the numbers of young people in the UK currently diagnosed schizophrenic who would not have become mentally ill if they had not used this drug.

曾经使用过大麻的年轻人患精神分裂症等精神病的风险增加40%;在那些大量使用大麻的人中，风险增加200%。寻求大麻成瘾治疗的年轻人人数也在迅速增加。《泰晤士报》最近在英国的头条新闻中写道：每周有500名大麻吸食者寻求医疗帮助？（2008年1月11日）。此外，大麻对大脑的影响引起了人们的担忧，即使用这种药物的年轻人可能在教育或工作中表现不佳。我们做什么？我还不明白为什么有些人可以使用大麻而没有明显的有害影响，而另一些人则会患上精神病或上瘾，或者注意力和记忆力有问题。在第一项同类研究中，我们最近发现，年轻人吸食的大麻中的两种主要成分（THC和CBD）会影响他们在日常生活中所经历的精神病样效应。这项研究建立在这一发现和我们最近对244名年轻人进行的评估大麻影响的大规模研究的基础上。它旨在确定哪些与大麻有关的因素和哪些个人因素使一些年轻人容易受到毒品的有害影响。它解决的三个主要危害是精神病样症状，成瘾和认知障碍。研究的第一阶段将是自然主义的，涉及600名16-23奥尔兹的大麻使用者。一些大麻使用者将被选中参加第二阶段-一项关于大麻两种主要成分（THC和CBD）单独和联合作用的受控实验室研究。在这两个阶段，我们将评估的影响是精神病样的，成瘾相关的和认知的。我们也会调查年轻人？关于不同大麻品种的信仰和观点，如臭鼬和辛塞米拉。在编写本提案时，政府正在等待另一次大麻分类审查的结果。无论这是否会导致它从C类提高到B类，对大麻使用者的影响都可以忽略不计。如果我们证明，如果脆弱的青少年选择CBD含量更高的菌株，或者如果他们服用CBD补充剂，那么有害影响可以减少，那么这可能会导致更安全的大麻使用新时代。重要的是，它可以显着减少英国目前被诊断为精神分裂症的年轻人的数量，如果他们没有使用这种药物，他们就不会患上精神病。