Identifying glaucoma risk variants in the Norfolk island genetic isolate

原发性开角型青光眼是最常见的青光眼。在这个项目中，我们将专注于识别影响这种疾病发展的功能遗传变异，使用强大的全外显子组测序方法，对来自诺福克岛人群分离的大型多代谱系进行分析。确定影响青光眼发展的基因将为确定这种常见疾病的病理生理学提供宝贵的线索。

Primary open angle glaucoma is the most common form of glaucoma. In this project we will focus on the identification of functional genetic variants influencing development of this disorder, using a powerful whole exome sequencing approach in a large multigenerational pedigree from the Norfolk Island population isolate. The identification of genes influencing glaucoma development would provide invaluable clues to aid in defining the pathophysiology of this common disease.