Identifying mitochondrial genome variants associated with familial migraine susceptibility

识别与家族性偏头痛易感性相关的线粒体基因组变异

• 批准号: nhmrc : GNT1083450
• 负责人: A/Pr Rod Lea
• 金额: $ 42.98万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identifying-mitochondrial-genome-migraine-susceptibility/1345507
• 关键词: Identifying; mitochondrial; genome; variants; associated

New therapeutic targets for migraine are desperately needed. Although studies have identified some migraine genes there remains considerable underlying genetic variation to be characterised. This study aims to identify functional variants in the mitochondrial genome that contribute to migraine susceptibility, utilising the isolated Norfolk Island population. Outcomes will determine the significance of the variants identified, potentially leading to new diagnostics.

迫切需要新的偏头痛治疗靶点。虽然研究已经确定了一些偏头痛基因，但仍有相当多的潜在遗传变异有待鉴定。本研究的目的是确定线粒体基因组的功能变异，有助于偏头痛的易感性，利用隔离的诺福克岛人口。结果将决定所识别的变异的重要性，可能导致新的诊断方法。