The role of ErbB-4 in inflammation-induced colon carcinogenesis

ErbB-4 在炎症诱导的结肠癌发生中的作用

• 批准号: 8195441
• 负责人: Mark R Frey
• 金额: $ 12.76万
• 依托单位: CHILDREN'S HOSPITAL OF LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8195441
• 关键词: Address; Allografting; Biological Assay; Cell Survival; Cells; Chemoprevention; Chronic; Colitis; Colon; Colon Carcinoma; Colorectal Cancer; Data; Disease; Environment; Epidermal Growth Factor Receptor; Epithelial Cells; Epithelium; ErbB4 gene; Family; Family member; Immigration; In Vitro; Individual; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Intestinal Neoplasms; Intestines; Large Intestine Carcinoma; Length; Modeling; Morbidity - disease rate; Mus; Pathologic; Patients; Protein Isoforms; Receptor Protein-Tyrosine Kinases; Relative (related person); Reporting; Research; Risk; Role; Signal Pathway; TNF gene; Testing; Tissues; base; carcinogenesis; cell transformation; colon carcinogenesis; cost; cytokine; early onset; high risk; in vitro Model; in vivo; intestinal epithelium; member; migration; mortality; novel; overexpression; research study; tumor; tumorigenesis

项目成果

A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide.

• DOI: 10.1242/dmm.013284
• 发表时间: 2013-11
• 期刊: Disease models & mechanisms
• 影响因子: 4.3
• 作者: Williams JM;Duckworth CA;Watson AJ;Frey MR;Miguel JC;Burkitt MD;Sutton R;Hughes KR;Hall LJ;Caamaño JH;Campbell BJ;Pritchard DM
• 通讯作者: Pritchard DM