FACULTY DVMT & CLIN BEHV RES CORES

教职人员 DVMT

• 批准号: 7961262
• 负责人: CARMEN D ZORRILLA
• 金额: $ 56.87万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-24 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7961262
• 关键词: AIDS/HIV problem; Adherence; Advisory Committees; Affect; American; Attention; Clinical; Clinical Psychology; Clinical Research; Collaborations; Communities; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Environment; Evaluation; Event; Faculty; Funding; General Population; Grant; HIV; Health Personnel; Hispanics; Homelessness; Human immunodeficiency virus test; Institution; Interdisciplinary Study; Internet; Intervention; Intervention Studies; Island; Journals; Laboratories; Latino; Lead; Measures; Mentors; Mentorship; Morbidity - disease rate; National Center for Research Resources; Outcome; Pharmaceutical Preparations; Pharmacy Schools; Pilot Projects; Population; Populations at Risk; Prevention; Preventive Intervention; Prostitution; Public Health; Public Health Schools; Publications; Publishing; Puerto Rican; Puerto Rico; Recording of previous events; Reporting; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Risk Behaviors; Risk Reduction; School Dentistry; Schools; Secondary Prevention; Series; Services; Source; Staging; Stigmata; Students; Training; Translational Research; United States National Institutes of Health; Universities; Violence; Woman; abuse neglect; acronyms; base; burden of illness; career; drug addict; essays; health disparity; innovation; instrument; interest; medical schools; programs; sex; social stigma

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction The activities of the Center have been carried out as proposed in our original plan. All of the originally proposed research projects (3) are during their last stages and developmental funding was provided to several pilot projects during the past year. In total there are 9 ongoing or active projects. We will be submitting a proposal for an additional year of partial funding ("bridge") to allow the Center to continue activities towards renewal or further funding as deemed advisable by the NCRR. We are including a list of 28 scientific publications from the key investigators and faculty involved in the Center. As part of this report we are describing the activities of the Core groups: the Faculty Development and Progress Evaluation Core, the Data Core and DSMB, both Internal and External Advisory Committees and the Laboratory Core. A report on the developmental research projects is included. II. Specific Aims of the Center At the end of the first funding cycle we completed all of our specific aims for this Center as follows: 1.To establish a Comprehensive Center with the purpose of enhancing the clinical and translational research capabilities in Puerto Rico through a collaborative effort between the three accredited Medical Schools in PR, the UPR School of Public Health and the UPR School of Dentistry to establish a "tradition" of collaboration The PR-CCHD was successful in establishing and retaining collaborators from the three accredited medical schools in PR plus several other programs adding to a total of six professional schools. The UPR School of Public Health, the UPR School of Dentistry, the Ponce School of Medicine Program of Clinical Psychology, the NOVA Southeastern School of Pharmacy and Iniciativa Comunitaria de Investigacion (ICI-Spanish acronym) were included as part of the collaborators. So, during the first funding cycle, the number of collaborating professional schools increased from the original three to six and one Community Based Organization (CBO). The junior investigators were encouraged to establish inter-institutional partnerships and research teams and this activity was enhanced by the mentoring and infrastructure support provided by the center. This is a unique and innovative Center since it clearly establishes a mechanism for collaborative research that integrates into one central concept the salient activities at each participating institution: a Data Center, a Laboratory and a Clinical Research Center. Although integration and collaboration has been the target of many initiatives, it is through the webbing of resources that true collaborative research was established as a tradition and not as an isolated event. This (tradition or culture of collaboration) will perhaps be one of the biggest and most important long-term accomplishments of this proposal. This tradition of collaboration stared with the lead investigators, but will be cemented by the long-term participation of junior investigators who will initiate their careers with a different paradigm: that successful collaboration can happen even within "competing" institutions. This will be in the benefit of all involved. 2. To develop sustainable, replicable and culturally appropriate prevention and/or intervention research programs targeted to the Puerto Rican population to decrease the burden of disease. Several prevention interventions were developed as part of the activities of the center, the most salient was the development of the Hispanic/Latino Respect (a risk reduction intervention using the rapid HIV test). 3. To develop and validate a series of culturally appropriate instruments to measure diverse variables such as but not limited to: socio-demographic, HIV risk behaviors, co-morbidities, adherence, stigma, history of violence and abuse; and to make them available to interested investigators and health care providers. Instruments were developed to adequately measure perceived stigma as well as abuse and neglect among populations at-risk for HIV/AIDS. 4. To enhance the opportunities for multidisciplinary research collaborations between the island institutions and those with a more established research programs in the US mainland. Collaborations with NOVA Southeastern University and other programs were initiated. 5. To establish a Mentorship program for junior investigators with resources from both local and abroad (PR and US institutions) and to create the stimulating academic environment that will encourage students and fellows to pursue a career in health disparities research and in particular, HIV/AIDS research. Based on the outcomes and the impact of the training and development activities performed in the last four years, we developed a mentoring/educational framework. An analytic essay/article was published in the American Journal of Public Health. (Rabionet, S, Santiago, L, and Zorrilla, C. 2009, Vol 99, No S1 65-70). In addition to the previously mentioned activities, another partner was included in the research activities: Iniciativa Comunitaria de Investigacion (ICI) is a community-based organization established in 1991 to provide comprehensive primary and secondary prevention and support services to people affected with HIV/AIDS. It originated from the CPCRA (Community Participatory Clinical Research Activities) funded by NIH to bring research activities to the community. ICI serves the general population with special attention to marginalized groups such as, homeless, drug addicts, and women who engage in commercial sex worker (sex for drugs/money).

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 介绍 中心的活动已按照我们原计划的建议进行。所有最初提出的研究项目 (3) 均处于最后阶段，并且在过去一年中为多个试点项目提供了开发资金。总共有 9 个正在进行或正在进行的项目。我们将提交一份额外一年部分资金（“过渡资金”）的提案，以便中心能够继续开展续展活动或根据 NCRR 的建议进行进一步资金支持。 我们列出了该中心主要研究人员和教员发表的 28 篇科学出版物。作为本报告的一部分，我们描述了核心小组的活动：教师发展和进步评估核心、数据核心和 DSMB、内部和外部咨询委员会以及实验室核心。其中包括一份关于发展研究项目的报告。 二.中心的具体目标 在第一个资助周期结束时，我们完成了该中心的所有具体目标，如下： 1.建立一个综合中心，旨在通过波多黎各三所认可的医学院、UPR公共卫生学院和UPR牙科学院之间的合作，建立合作“传统”，提高波多黎各的临床和转化研究能力 PR-CCHD 成功地建立并保留了来自 PR 认可的三所医学院以及其他几个项目的合作者，总共有六所专业学校。 UPR公共卫生学院、UPR牙科学院、庞塞医学院临床心理学项目、NOVA东南药学院和Iniciativa Comunitaria de Investigacion（ICI-西班牙语缩写）均属于合作者。因此，在第一个资助周期内，合作专业学校的数量从原来的三所增加到六所和一个社区组织（CBO）。 鼓励初级研究人员建立机构间合作伙伴关系和研究团队，并且该中心提供的指导和基础设施支持加强了这项活动。 这是一个独特且创新的中心，因为它明确建立了一种合作研究机制，将每个参与机构的显着活动融入一个中心概念：数据中心、实验室和临床研究中心。尽管整合和协作一直是许多举措的目标，但正是通过资源网络，真正的协作研究才成为一种传统，而不是一个孤立的事件。这（合作的传统或文化）也许将是该提案最大和最重要的长期成就之一。这种合作传统始于主要研究人员，但将通过初级研究人员的长期参与得到巩固，他们将以不同的范式开始他们的职业生涯：即使在“竞争”机构内也可以发生成功的合作。这将有利于所有相关人员。 2. 制定针对波多黎各人口的可持续、可复制和文化上适当的预防和/或干预研究计划，以减轻疾病负担。 作为该中心活动的一部分，制定了多项预防干预措施，其中最突出的是制定西班牙裔/拉丁裔尊重（使用快速艾滋病毒检测的降低风险干预措施）。 3. 开发和验证一系列适合文化的工具来衡量不同的变量，例如但不限于：社会人口、艾滋病毒危险行为、共病、依从性、耻辱、暴力和虐待史；并将其提供给感兴趣的研究人员和医疗保健提供者。 开发了一些工具来充分衡量艾滋病毒/艾滋病高危人群所感受到的耻辱以及虐待和忽视。 4. 增加岛屿机构与美国大陆拥有更成熟研究项目的机构之间多学科研究合作的机会。 与 NOVA 东南大学及其他项目的合作已启动。 5. 利用本地和国外（公关和美国机构）的资源，为初级研究人员建立导师计划，并创造激励性的学术环境，鼓励学生和研究员从事健康差异研究，特别是艾滋病毒/艾滋病研究。 根据过去四年进行的培训和发展活动的成果和影响，我们制定了指导/教育框架。一篇分析文章/文章发表在《美国公共卫生杂志》上。 （Rabionet, S、Santiago, L 和 Zorrilla, C. 2009 年，第 99 卷，第 S1 65-70 期）。 除了前面提到的活动外，研究活动中还包括另一个合作伙伴：Iniciativa Comunitaria de Investigacion (ICI) 是一个成立于 1991 年的社区组织，旨在为艾滋病毒/艾滋病患者提供全面的初级和二级预防和支持服务。它起源于NIH资助的CPCRA（社区参与性临床研究活动），旨在将研究活动带入社区。 ICI 服务于普通大众，特别关注边缘群体，例如无家可归者、吸毒者和从事商业性工作者（以性换取毒品/金钱）的妇女。