Identifying the mechanisms by which ascorbate stimulates cellular iron uptake from transferrin.

确定抗坏血酸刺激细胞从转铁蛋白摄取铁的机制。

• 批准号: nhmrc : 1013810
• 负责人: Dr Darius Lane
• 金额: $ 20.15万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identifying-mechanisms-ascorbate-uptake-transferrin/109752
• 关键词: Identifying; mechanisms; ascorbate; stimulates; cellular

Vitamin C (ascorbate)-deficiency leads to anaemia and other symptoms of scurvy. Iron supplementation cannot alone correct this anaemia, with ascorbate being crucial. Almost all iron in plasma is bound to transferrin, and I have recent data showing that ascorbate stimulates transferrin-iron uptake. This research will identify how this stimulation occurs. This work has important biomedical implications for understanding iron uptake and anaemia, which affects 500 million people globally.

维生素 C（抗坏血酸）缺乏会导致贫血和其他坏血病症状。仅补充铁质并不能纠正这种贫血，其中抗坏血酸至关重要。血浆中几乎所有的铁都与转铁蛋白结合，我最近的数据显示抗坏血酸会刺激转铁蛋白-铁的吸收。这项研究将确定这种刺激是如何发生的。这项工作对于了解铁吸收和贫血症具有重要的生物医学意义，贫血症影响着全球 5 亿人。