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Career Enhancement for Epigenetic Research on Substance Abuse and Comorbidities

药物滥用和合并症表观遗传学研究的职业提升

基本信息

批准号：
8033447
负责人：
Bernice A. Pescosolido
金额：
$ 15.08万
依托单位：
TRUSTEES OF INDIANA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-30 至 2012-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8033447
关键词：
Address Alcohol dependence Area Basic Behavioral and Social Science Research Behavioral Genetics Biological Biology Biomedical Research Candidate Disease Gene Cholera Chromosomes Collaborations Communicable Diseases Comorbidity Complex Coupled Data Data Collection Disease Drug abuse Electronics Epigenetic Process Family Fostering Gene Cluster Genes Genetic Genetic Predisposition to Disease Health Infection Infectious Agent Infusion procedures Interdisciplinary Study Joints Knowledge Language Life Medical Mental Health Mentors Methods Modeling Molecular Molecular Genetics National Research Council Neurosciences Outcome Pathway interactions Physiology Process Psychiatry Reporting Research Research Ethics Research Project Grants Research Training Science Scientist Series Shapes Social Environment Social Network Social Sciences Societies Sociology Solutions Stratification Substance Use Disorder Substance abuse problem System Techniques Time Training Tuberculosis United States National Academy of Sciences Virulence Work abstracting base behavioral/social science career design forging genetics of alcoholism improved insight interdisciplinary approach interdisciplinary collaboration multidisciplinary proband professor programs severe mental illness social sociologist theories tool

项目摘要

DESCRIPTION (provided by applicant): Career Enhancement for Epigenetic Research on Substance Abuse and Comorbidities This application addresses the call for further progress on the epigenetic agenda which requires a shift from a multidisciplinary approach (experts in scientific fields bringing disciplinary insights) to an interdisciplinary approach (disciplinary-based scientists sharing a basic understanding of each other's language, theories, methods of data collection and analytic techniques). The proposed activities will foster greater synergy and bring a complex approach to the conceptualization and conduct of research on the epigenetics of substance use disorders (SUDs) and their comorbidity with serious mental illness (SMIs). Two specific aims are designed to: 1) Engage in a short-term, intense training plan to better integrate the centrality and presence of basic behavioral and social science research (b-BSSR) on an interdisciplinary team focused on the onset of SUDs and their comorbidity with SMIs by increasing knowledge of biomedical research (BMR) theories, tools, methods of data collection, and analytic techniques. This includes 1.a.) Improve understanding of basic and behavioral genetics, physiology, and neuroscience through a series of face-to-face and electronic courses over a 12 month period; and 1.b) Improve knowledge of research ethics targeted to the unique issues that arise in research on genetics and epigenetics relevant to SUDSs and their comorbidity with SMIs; 2) Develop and carry out a research project that brings b-BSSR theories and analytic approaches into an established research program focusing on genetic and epigenetic analyses of one of the premier BMR data programs, the Collaborative Study of the Genetics of Alcoholism (COGA, N= 10,646 probands, families and controls). More specifically, 2.a.) Reconceptualize and empirically examine current epigenetic models of SUDs, including polyuse and comorbidity problems as representing differential pathways by which b-BSSR theories of illness interact with (or work through) each other, candidate genes and gene clusters. Building on the base of an initial productive, multidisciplinary collaboration, this application, with Bernice A. Pescosolido (Distinguished Professor of Sociology) as PI/Candidate and John Nurnberger, Jr. (Joyce and Iver Small Professor of Psychiatry and Professor of Medical and Molecular Genetics) as Mentor, requests one year of protected time designed to achieve a shift in the focus of research. This will be accomplished in part through additional training that will enrich a current research program designed to improve interdisciplinary collaborations on issues of SUDs and comorbidity by enhancing the ability of b-BSSR scientists to integrate tools and approaches from other related science areas. PUBLIC HEALTH RELEVANCE: The complex causes of substance abuse disorders, including the use of multiple substances (polyuse) and co- occurrence with mental health problems (comorbidity) require scientists from both the biomedical and social sciences to pool their expertise to understand and offer solutions. Building on an initial, productive collaboration between a sociologist and a medical/molecular geneticist, this project provides opportunities for targeted training and research to facilitate a research agenda focused on how the social environment triggers, suppresses or otherwise is involved in genetic predispositions to substance abuse and comorbidity.

描述（由申请人提供）：药物滥用和合并症表观遗传学研究的职业提升本申请呼吁表观遗传学议程取得进一步进展，这需要从多学科方法（科学领域的专家带来学科见解）转向跨学科方法（基于学科的科学家对彼此的语言、理论、数据收集方法和分析技术有基本的了解）。拟议的活动将促进更大的协同作用，并为物质使用障碍（SUD）的表观遗传学及其与严重精神疾病（SMI）的共病的概念化和研究提供复杂的方法。设计了两个具体目标：1) 参与短期、密集的培训计划，通过增加生物医学研究 (BMR) 理论、工具、数据收集方法和分析技术的知识，更好地将基本行为和社会科学研究 (b-BSSR) 的中心地位和存在整合到跨学科团队中，重点关注 SUD 的发病及其与 SMI 的合并症。这包括 1.a.) 通过为期 12 个月的一系列面对面和电子课程，提高对基础和行为遗传学、生理学和神经科学的理解； 1.b) 针对与 SUDS 相关的遗传学和表观遗传学研究中出现的独特问题及其与 SMI 的共病，提高研究伦理知识； 2) 开发并实施一个研究项目，将 b-BSSR 理论和分析方法纳入已建立的研究计划中，重点关注主要 BMR 数据计划之一的遗传和表观遗传学分析，即酒精中毒遗传学合作研究（COGA，N = 10,646 个先证者、家庭和对照）。更具体地说，2.a.) 重新概念化并凭经验检验当前 SUD 的表观遗传模型，包括多用和合并症问题，代表 b-BSSR 疾病理论与候选基因和基因簇相互作用（或起作用）的差异途径。该申请建立在最初富有成效的多学科合作的基础上，由 Bernice A. Pescosolido（社会学杰出教授）担任 PI/候选人，John Nurnberger, Jr.（Joyce 和 Iver Small 精神病学教授以及医学和分子遗传学教授）担任导师，要求一年的保护时间，旨在实现研究重点的转变。这将部分通过额外的培训来实现，这些培训将丰富当前的研究计划，旨在通过增强 b-BSSR 科学家整合其他相关科学领域的工具和方法的能力，改善 SUD 和合并症问题的跨学科合作。公共卫生相关性：药物滥用障碍的复杂原因，包括使用多种物质（多次使用）以及与心理健康问题同时发生（合并症），需要生物医学和社会科学领域的科学家汇集其专业知识来理解并提供解决方案。该项目以社会学家和医学/分子遗传学家之间初步、富有成效的合作为基础，提供了有针对性的培训和研究机会，以促进研究议程的重点是社会环境如何触发、抑制或以其他方式参与药物滥用和合并症的遗传倾向。