Identifying the molecular basis of memory B cell function and human immunoglobulin E memory via Hyper Immunoglobulin E Syndromes

通过高免疫球蛋白 E 综合征识别记忆 B 细胞功能和人免疫球蛋白 E 记忆的分子基础

• 批准号: nhmrc : 2002673
• 金额: $ 9.6万
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identifying-molecular-basis-e-syndromes/1780443
• 关键词: Identifying; molecular; basis; memory; cell

Memory B cells generate rapid and potent antibody responses to known threats. The molecular basis for this is unknown, but defects increase the risk of infection, autoimmunity, and allergy. Autoimmunity and allergy are often mediated by a poorly understood antibody subclass, immunoglobulin E (IgE). My project will use emerging single-cell technologies to reveal the molecular mechanisms of antibody memory and IgE regulation, enabling the design of superior vaccines and immunomodulatory therapy.

记忆B细胞对已知的威胁产生快速而有效的抗体反应。其分子基础尚不清楚，但缺陷会增加感染、自身免疫和过敏的风险。自身免疫和变态反应通常是由一个了解甚少的抗体亚类，免疫球蛋白E（IgE）介导的。我的项目将使用新兴的单细胞技术来揭示抗体记忆和IgE调节的分子机制，从而设计出上级疫苗和免疫调节治疗。