B cell antigen presentation in chronic allergic lung disease (asthma)

慢性过敏性肺病（哮喘）中的 B 细胞抗原呈递

• 批准号: 7586894
• 负责人: DENNIS M LINDELL
• 金额: $ 16.2万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-15 至 2012-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7586894
• 关键词: Accounting; Affect; Allergic; Allergic Disease; Antibody Formation; Antigen Presentation; Antigen-Presenting Cells; Antigens; Asthma; Attenuated; B-Lymphocytes; CD4 Positive T Lymphocytes; Cell physiology; Chronic; Chronic Disease; Collaborations; Data; Developed Countries; Development; Disease; Endotoxins; Eosinophilia; Equilibrium; Event; Extrinsic asthma; Foundations; Functional disorder; Future; Genetic; Hypersensitivity skin testing; IgE; Immune system; Immunoglobulins; Immunology; In Vitro; Inflammation; Interleukin-13; Interleukin-4; Interleukin-5; Leukocytes; Lung; Lung diseases; Maintenance; Modeling; Mus; Play; Prevalence; Process; Production; Recruitment Activity; Regulation; Relative (related person); Research Design; Role; Shapes; Stimulus; Structure of parenchyma of lung; T cell differentiation; T cell response; T-Lymphocyte; Th2 Cells; airway remodeling; clinically relevant; cockroach allergen; cytokine; immune activation; in vivo; insight; mast cell; mouse model; response

DESCRIPTION (provided by applicant): In recent decades, the prevalence of asthma in the US and other industrialized countries has increased dramatically. Chronic allergic lung disease (allergic asthma) accounts for a majority of asthma. Many studies have demonstrated that Th2 cells and Th2 cytokines including IL-4, IL-5, and IL-13 play an important role in the development of allergic lung disease and the downstream events, including inflammation, eosinophilia, mast cell accumulation/activation, and airway remodeling. However, less is known about the mechanisms that affect the development and maintenance of Th2 cells. The proliferation and differentiation of naive T cells is triggered by interactions with antigen presenting cells bearing cognate antigen. It is becoming increasing clear that the conditions surrounding this interaction influence T cell differentiation. This proposal will investigate the role that B cells have in shaping the T cell response during chronic allergic lung disease. In addition, the role of important innate molecules will be investigated for their contribution to the regulation of B cell antigen presentation. In these studies, we investigate the role of B cells in chronic allergic lung disease, with an emphasis on the role of B cells as antigen presenting cells. These specific aims will build a foundation for investigating the role of B cells in allergic disease, but these studies will have relevance for understanding the role of B cells in the immunology of other chronic diseases. RELEVANCE: Chronic allergic lung disease (asthma) is characterized by inappropriate activation of the immune system. B cells are a significant contributor to this and other chronic diseases. This project focuses on the role of B cells in perpetuating allergic disease, but will give insights into how B cells contribute to the balance of tolerance versus immune activation in a variety of other diseases, as well.

描述（由申请人提供）：近几十年来，美国和其他工业化国家的哮喘患病率急剧增加。慢性过敏性肺病（过敏性哮喘）占哮喘的大部分。 许多研究表明，Th 2细胞和Th 2细胞因子（包括IL-4、IL-5和IL-13）在变应性肺病的发展及其下游事件（包括炎症、嗜酸性粒细胞增多、肥大细胞积聚/激活和气道重塑）中起重要作用。然而，对影响Th 2细胞发育和维持的机制知之甚少。幼稚T细胞的增殖和分化是通过与携带同源抗原的抗原呈递细胞的相互作用触发的。越来越清楚的是，这种相互作用周围的条件影响T细胞分化。这项提案将调查的作用，B细胞在塑造T细胞反应在慢性过敏性肺病。此外，重要的先天性分子的作用将被调查，为他们的贡献调节B细胞抗原呈递。在这些研究中，我们研究了B细胞在慢性变应性肺病中的作用，重点是B细胞作为抗原呈递细胞的作用。这些特定的目标将为研究B细胞在过敏性疾病中的作用奠定基础，但这些研究将对理解B细胞在其他慢性疾病免疫学中的作用具有相关性。 相关性：慢性过敏性肺病（哮喘）的特征是免疫系统的不适当激活。B细胞是这种疾病和其他慢性疾病的重要贡献者。该项目的重点是B细胞在维持过敏性疾病中的作用，但也将深入了解B细胞如何在各种其他疾病中促进耐受性与免疫激活的平衡。