Identifying novel pathways of red blood cell differentiation by CRISPR screening

通过 CRISPR 筛选鉴定红细胞分化的新途径

• 批准号: nhmrc : GNT1158053
• 负责人: Dr Beeke Wienert
• 金额: $ 41.72万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identifying-novel-pathways-crispr-screening/1349251
• 关键词: Identifying; novel; pathways; red; blood

Red blood cells supply all organs with oxygen and are essential to the health of all vertebrate organisms. Thus, disorders affecting red blood cells can have devastating outcomes for patients. In some diseases, blood progenitor cells fail to fully mature into red blood cells which results in a shortage of red blood cells. Hence, my aim is to better understand the molecular processes of red blood cell maturation to discover novel therapeutic targets for red blood cell disorders.

红细胞为所有器官提供氧气，对所有脊椎动物的健康至关重要。因此，影响红细胞的疾病可能会对患者造成毁灭性的后果。在某些疾病中，血液祖细胞不能完全成熟为红细胞，导致红细胞短缺。因此，我的目标是更好地了解红细胞成熟的分子过程，以发现红细胞疾病的新治疗靶点。