Identifying novel pathways of red blood cell differentiation by CRISPR screening

红细胞为所有器官提供氧气，对所有脊椎动物的健康至关重要。因此，影响红细胞的疾病可能对患者造成毁灭性的后果。在一些疾病中，血液祖细胞不能完全成熟为红细胞，导致红细胞短缺。因此，我的目标是更好地了解红细胞成熟的分子过程，以发现红细胞疾病的新治疗靶点。

Red blood cells supply all organs with oxygen and are essential to the health of all vertebrate organisms. Thus, disorders affecting red blood cells can have devastating outcomes for patients. In some diseases, blood progenitor cells fail to fully mature into red blood cells which results in a shortage of red blood cells. Hence, my aim is to better understand the molecular processes of red blood cell maturation to discover novel therapeutic targets for red blood cell disorders.