AMICA: A New Costimulatory Molecule GammaDelta T Cells
AMICA:一种新的共刺激分子 GammaDelta T 细胞
基本信息
- 批准号:7727372
- 负责人:
- 金额:$ 44.68万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-12-01 至 2011-11-30
- 项目状态:已结题
- 来源:
- 关键词:AdhesionsAdultAffectAntigen-Presenting CellsAntigensApoptoticAutoantigensBindingCD28 geneCD8B1 geneCell CommunicationCell physiologyCellsDataDiseaseEpithelialEpithelial CellsEventFamilyHomeostasisImmune responseIn VitroIntegrinsIntestinesKnock-outLigandsLigationLymphoidLymphoid CellMediatingMitogensMusPlayPopulationProductionRestRoleSignal TransductionSiteSkinSurfaceT cell responseT-Cell ProliferationT-Cell ReceptorT-LymphocyteT-Lymphocyte SubsetsTestingTissuesWound Healingcytokinejunctional adhesion moleculekeratinocytemembernovelprogramsprototypereceptorrepairedresearch studyresponse
项目摘要
T cells bearing invariant y5 T cell antigen receptors (TCR) localize to distinct epithelial sites in
the adult mouse where they interact with non-classical antigen presenting cells such as epithelial
cells. Many of these y8 T cell populations do not express traditional costimulatory molecules
such as CD28 suggesting that they may rely on signals delivered through novel receptor-ligand
interactions. We have identified AMIGA, a member of the junctional adhesion molecule family,
as a costimulatory molecule for epithelial y8 T cells. AMIGA is expressed on all y5 T cells and
in vitro mitogen activation leads to upregulated surface expression. Among lymphoid cells,
AMIGA is preferentially expressed by y8 T cells although a small subpopulation of CD8+ ap T
cells also express AMIGA after activation. Signals delivered through AMIGA costimulate skin
and intestinal y5 T cell proliferation and cytokine release but not activation of any ap T cells or
lymphoid y5 T cells. We will test the hypothesis that AMIGA expressed by epithelial y8 T cells
binds to a ligand expressed on damaged epithelial cells and that interaction between this novel
receptor-ligand pair delivers costimulatory signals to the y8T cell that are critical for
participation in local immune responses including tissue homeostasis and repair. Together these
studies should determine the roles of AMIGA in the activation and function of epithelial y8 T
cells and may be applicable for manipulation of y8 T cell responses in epithelial disorders.
携带不变 y5 T 细胞抗原受体 (TCR) 的 T 细胞定位于不同的上皮位点
成年小鼠与非经典抗原呈递细胞(例如上皮细胞)相互作用
细胞。许多 y8 T 细胞群不表达传统的共刺激分子
例如 CD28 表明它们可能依赖于通过新型受体-配体传递的信号
互动。我们已经鉴定出 AMIGA,它是连接粘附分子家族的成员,
作为上皮 y8 T 细胞的共刺激分子。 AMIGA 在所有 y5 T 细胞上表达
体外有丝分裂原激活导致表面表达上调。在淋巴细胞中,
AMIGA 优先由 y8 T 细胞表达,尽管 CD8+ ap T 细胞有一小部分亚群
细胞在激活后也表达AMIGA。通过 AMIGA 共刺激皮肤传递信号
和肠道 y5 T 细胞增殖和细胞因子释放,但不激活任何 ap T 细胞或
淋巴 y5 T 细胞。我们将检验上皮 y8 T 细胞表达 AMIGA 的假设
与受损上皮细胞上表达的配体结合,并且这种新颖的相互作用
受体-配体对向 y8T 细胞传递共刺激信号,这对
参与局部免疫反应,包括组织稳态和修复。一起这些
研究应确定 AMIGA 在上皮 y8 T 激活和功能中的作用
细胞,可能适用于操纵上皮疾病中的 y8 T 细胞反应。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Wendy L. Havran其他文献
Oiling the wheels of autoimmunity
给自身免疫的车轮上油
- DOI:
10.1038/506042a - 发表时间:
2014-02-05 - 期刊:
- 影响因子:48.500
- 作者:
Mitchell Kronenberg;Wendy L. Havran - 通讯作者:
Wendy L. Havran
The Biology of <em>γδ</em> T Cells: What Is the Relationship between <em>γδ</em> T Cells and Cancer? Will an Increased Number and/or Function of <em>γδ</em> T Cells Result in Lower Cancer Incidence?
- DOI:
10.1093/jn/135.12.2909s - 发表时间:
2005-12-01 - 期刊:
- 影响因子:
- 作者:
Wendy L. Havran - 通讯作者:
Wendy L. Havran
γδ T cells and IgE team up to prevent tumors
γδ T 细胞和免疫球蛋白 E 联手预防肿瘤
- DOI:
10.1038/s41590-018-0167-2 - 发表时间:
2018-07-16 - 期刊:
- 影响因子:27.600
- 作者:
J. Michael McGraw;Wendy L. Havran - 通讯作者:
Wendy L. Havran
Wendy L. Havran的其他文献
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{{ truncateString('Wendy L. Havran', 18)}}的其他基金
Expression of gamma delta TCR ligands in development
发育中γδTCR配体的表达
- 批准号:
9332915 - 财政年份:2017
- 资助金额:
$ 44.68万 - 项目类别:
Mechanism-Based Wound Healing by Activation of gamma delta T Cells
通过激活 γ δ T 细胞实现基于机制的伤口愈合
- 批准号:
9104102 - 财政年份:2015
- 资助金额:
$ 44.68万 - 项目类别:
Mechanism-Based Wound Healing by Activation of gamma delta T Cells
通过激活 γ δ T 细胞实现基于机制的伤口愈合
- 批准号:
8954537 - 财政年份:2015
- 资助金额:
$ 44.68万 - 项目类别:
Role of EPCR in gamma delta T cell wound healing functions
EPCR 在 γδT 细胞伤口愈合功能中的作用
- 批准号:
8571495 - 财政年份:2013
- 资助金额:
$ 44.68万 - 项目类别:
Role of EPCR in gamma delta T cell wound healing functions
EPCR 在 γδT 细胞伤口愈合功能中的作用
- 批准号:
8672596 - 财政年份:2013
- 资助金额:
$ 44.68万 - 项目类别:
Identification of skin gamma delta T cell antigens
皮肤 γ δ T 细胞抗原的鉴定
- 批准号:
8269042 - 财政年份:2011
- 资助金额:
$ 44.68万 - 项目类别:
Identification of skin gamma delta T cell antigens
皮肤 γ δ T 细胞抗原的鉴定
- 批准号:
8177647 - 财政年份:2011
- 资助金额:
$ 44.68万 - 项目类别:
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