GASTROINTESTINAL DISEASE IN CAPTIVE RHESUS MACAQUES

圈养恒河猴的胃肠道疾病

基本信息

批准号：
7958701
负责人：
Elizabeth Schmidt Didier
金额：
$ 5.8万
依托单位：
TULANE UNIVERSITY OF LOUISIANA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-05-01 至 2010-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7958701
关键词：
Admission activity Affect Age Algorithms Animal Husbandry Animals Bacteria Body Weight Body Weight decreased Breeding Calicivirus Campylobacter Clinical Clinical Data Computer Retrieval of Information on Scientific Projects Database Data Demographic Factors Detection Diagnosis Diagnostic Diarrhea Enteral Etiology Female Fever Funding Future Gastrointestinal Diseases Gender Genotype Gluten Goals Grant Housing Immune Incidence Infectious Agent Institution Intervention Laboratories Location Macaca mulatta Measures Medical History Microsporidia Modeling Modification Morbidity - disease rate Outcome Study Population Sizes Pregnancy Outcome Prevalence Primates Procedures Protocols documentation Quarantine Research Research Personnel Research Project Grants Resources Risk Risk Factors Role Rotavirus Sanitation Services Source Testing United States National Institutes of Health Virus base human disease improved male nonhuman primate

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Persistent diarrhea is the predominant clinical sign of gastrointestinal (GI) disease and is one of the leading causes of morbidity in captive nonhuman primates (NHPs). It has been estimated that in approximately 50% of cases, the etiology of diarrhea is undetermined. The purpose of this resource-related research project proposal is to examine the role of selected, recently recognized and/or under-diagnosed causes of GI disease in the TNPRC rhesus breeding colonies and to develop intervention strategies that can be applied toward the long-term goal of reducing morbidity in rhesus macaques at the TNPRC. To begin to achieve these goals, the specific aims are; 1) Determine the prevalence and incidence of selected, recently recognized and/or under-diagnosed infectious causes of GI disease in rhesus macaques at the TNPRC to evaluate their association and risk with GI disease. The agents will include bacteria (Campylobacter), viruses (calicivirus and rotavirus), and the enteric parasitic microsporidia. 2) Evaluate the association between dietary gluten sensitivity in relation to GI disease, immune status, and demographic factors. These infectious agents (species or genotypes) and dietary sensitivity are currently not included on the routine diagnostic protocols provided by the core service laboratories at the TNPRC but have been recently recognized as probable contributors to overall morbidity attributable to GI disease in NHPs at the TNPRC. 3) Develop intervention strategies for reducing the incidence of GI disease. Prevalence, clinical, and demographic data generated in aims 1 and 2 will be evaluated by statistical analyses to measure risk factors associated with GI disease. Prevalence data will be based on the detection of the selected agents suspected of contributing to GI disease. The clinical data will primarily include occurrence of diarrhea, weight loss, and fever. Demographic information will include age, gender, body weight, housing conditions (location, field cage size, population size, female:male ratio), seasonality, and medical history (previous clinical admissions and cause, pregnancy outcomes). The results will be used to generate intervention strategies or algorithms that subsequently can be applied in future studies to test proof of concept. Predicted strategies include the implementation of new protocols in the TNPRC diagnostic core laboratories, selectivity in treatment, modification of sanitation procedures, relocation or limited quarantine of affected animals, dietary changes, and changes in animal husbandry practices. The outcome of this study is expected to improve the resource value of the NHPs that are used as models to study human disease.

该副本是利用众多研究子项目之一由NIH/NCRR资助的中心赠款提供的资源。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是对于中心，这不一定是调查员的机构。持续性腹泻是胃肠道（GI）疾病的主要临床征兆，是圈养非人类灵长类动物（NHP）发病的主要原因之一。据估计，在大约50％的病例中，腹泻病因是不确定的。这项与资源相关的研究项目建议的目的是研究gi疾病在TNPRC恒河猴育种菌落中所选的，最近认可和/或未经诊断的胃病原因的作用，并制定可用于降低TNPRC恒河麦卡克斯中发病率的长期目标的干预策略。为了开始实现这些目标，具体的目标是： 1）确定TNPRC恒河猕猴中诊断为胃肠道疾病的选定，最近认可和/或未被诊断出的传染病的患病率和发生率，以评估其与胃肠道疾病的关联和风险。这些药物将包括细菌（弯曲杆菌），病毒（彩色病毒和轮状病毒）以及肠寄生虫孢子虫。 2）评估与胃肠道疾病，免疫状态和人口统计学因素有关的饮食麸质敏感性之间的关联。目前，这些感染剂（物种或基因型）和饮食敏感性目前不包括在TNPRC的核心服务实验室提供的常规诊断方案中，但最近被认为是TNPRC中NHP中GI疾病的总体发病率的可能性。 3）制定降低胃肠道疾病发生率的干预策略。 AIM 1和2中产生的患病率，临床和人口统计数据将通过统计分析评估，以衡量与GI疾病相关的危险因素。患病率数据将基于对涉及胃肠道疾病的所选药物的检测。临床数据主要包括腹泻，体重减轻和发烧的发生。人口统计信息将包括年龄，性别，体重，住房条件（位置，田野大小，人口大小，女性：男性比率），季节性和病史（以前的临床入院和原因，怀孕结果）。结果将用于生成干预策略或算法，随后可以在未来的研究中应用，以测试概念证明。预测的策略包括在TNPRC诊断核心实验室中实施新方案，治疗的选择性，卫生程序的修改，搬迁或受影响动物的有限隔离，饮食变化以及畜牧业习俗的变化。这项研究的结果有望提高NHP的资源价值，这些NHP被用作研究人类疾病的模型。