Identifying regulators of the DNA damage response and tumourigenesis using C. elegans

使用线虫识别 DNA 损伤反应和肿瘤发生的调节因子

• 批准号: nhmrc : 1009172
• 负责人: Dr Hannah Nicholas
• 金额: $ 34.3万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identifying-regulators-dna-c-elegans/109378
• 关键词: Identifying; regulators; DNA; damage; response

By the age of 85, one in two men and one in three women in Australia will develop cancer. Regrettably, not all cancers respond to current therapies. Recently a new mechanism that prevents certain cancers from responding to chemotherapy has been identified, involving a protein called HIPK. We are using a simple model system, the nematode Caenorhabditis elegans, to discover ways in which this block to successful cancer treatment can be overcome, with the view to developing new therapeutic agents.

到85岁时，澳大利亚每两名男性和三名女性中就有一人会患上癌症。令人遗憾的是，并非所有癌症都对目前的疗法有反应。最近发现了一种阻止某些癌症对化疗反应的新机制，涉及一种名为HIPK的蛋白质。我们正在使用一个简单的模型系统，线虫秀丽隐杆线虫，以发现如何克服这种障碍，以成功的癌症治疗，以期开发新的治疗药物。