Novel adjuvants acting through TLR2, TLR5 and TLR7 receptors

先天免疫受体和佐剂发现项目的目标是发现、表征和支持基于触发人类先天免疫系统的新佐剂候选的临床前测试。佐剂被定义为通过先天免疫受体起作用的分子，以激活有益的先天和/或适应性（T和B细胞介导）免疫反应。利用高通量筛选技术，研究人员将筛选化合物文库，以确定潜在的佐剂产品，这些佐剂产品可能被开发成抗原特异性疫苗的成分，以对抗传染病，或者可能作为短暂预防或治疗传染病的独立药物。

The goals of the Innate Immune Receptors and Adjuvant Discovery program are to discover, characterize, and support preclinical testing of new adjuvant candidates based upon triggering of the human innate immune system. Adjuvants are defined as molecules that act via innate immune receptors to activate beneficial innate and/or adaptive (T and B cell-mediated) immune responses. Using high throughput screening techniques, investigators will screen compound libraries to identify potential adjuvant products that may be developed as components of antigen specific vaccines against infectious disease, or may serve as stand-alone agents that transiently prevent or treat infectious disease.