Develop a candidate subunit vaccine for Powassan Virus and West Nile virus adjuvanted with Alhydroxiquim-II

波瓦桑病毒是一种黄病毒，可由至少六种蜱属硬蜱科和皮蜱科传播，可引起严重脑炎和神经系统后遗症。它是北美唯一的蜱传黄病毒。西尼罗河病毒也是一种黄病毒，主要由库蚊传播，宿主范围广泛，可引起脑炎或脑膜炎，患者需要很长时间才能康复。目前还没有针对这两种疾病的人类疫苗。承包商将利用他们以前在其他黄病毒疫苗上的工作经验，生产新的亚单位疫苗，并将其与用于Covaxin COVID疫苗的佐剂alhydroxiquin - ii一起配制。

Powassan virus is a flavivirus that can be transmitted by at least six tick species within the Ixodes and Dermacentor families, and can cause severe encephalitis and neurologic sequelae. It is the only tick-borne flavivirus endemic in North America. West Nile virus, also a flavivirus, is mostly transmitted by Culex mosquitoes, has a broad host range, and can cause encephalitis or meningitis associated with lengthy patient recovery. No human vaccine is currently available for either disease. The contractor will generate novel subunit vaccines, applying the lessons learned from their previous work with other flavivirus vaccines, and formulate it with Alhydroxiquim-II, an adjuvant that is used in the Covaxin COVID vaccine.