Career Support and Mentoring of Interdisciplinary Alcohol Research

描述(由申请人提供)：有了这个高级科学家研究和导师奖(KO5)，候选人将为3-5名对跨学科酒精研究感兴趣的教职员工提供指导。初级教职员工或受过严格纪律培训的教职员工将优先考虑对酒精领域的新手。这位候选人已经在酒精领域拥有成功的导师和科学领导的持续记录。指导将包括关于拨款撰写和其他技能的指导，他们研究计划的发展，专业发展以及如何在跨学科团队中有效地工作。为了保持候选人作为科学领袖的表现，候选人将继续在耶鲁大学和全国范围内的跨学科研究方面进行广泛的合作。科学的持续增长将受益于与研究、指导、参与研究审查和咨询小组参与有关的活动。此外，她还将通过心理治疗干预、药物治疗开发和人类生物行为实验室研究等临床研究，继续为酗酒领域做出贡献。在这个研究项目中，酒精和烟草使用的相互影响将被考虑在内。例如，该研究计划提出了一项由R01资助的关于纳曲酮和基础咨询的研究，以减少18-25岁年轻人的大量饮酒。这项研究整合了基础研究、人体实验室研究、调查研究和临床试验中关于纳曲酮的信息，以优化年轻人的使用，这些年轻人接受短暂的咨询，以激励和传授减少饮酒的技能。纳曲酮在这一人群中的有效性的证明将为大学咨询中心和其他致力于降低年轻人酗酒风险的医疗机构采用纳曲酮提供必要的信息。最终，在这一关键时期的早期意图可能会通过改变饮酒轨迹而产生长期的好处。未来的研究计划包括对现有临床试验进行二次分析，使用人体实验室范例筛选治疗酒精依赖的新药，以及对有前景的化合物进行临床试验。 公共卫生相关性：通过跨学科的方法来了解和解决有害的酒精使用和酒精依赖问题，有可能极大地提高预防和治疗酒精依赖的有效性。这一奖项将有助于培训跨学科酒精研究的新调查人员。

DESCRIPTION (provided by applicant): With this Senior Scientist Research and Mentorship Award (KO5), the Candidate will provide mentorship to 3- 5 faculty interested in interdisciplinary alcohol research. Preference will be given to junior faculty or faculty with strong disciplinary training who are new to the alcohol area. The Candidate already has a sustained track record of successful mentorship and scientific leadership in the alcohol field. Mentorship will include guidance on grant writing and other skills, the development of their research program, professional development and how to effectively work within interdisciplinary teams. In order to sustain the Candidate's performance as a scientific leader, the Candidate will continue extensive collaborations in interdisciplinary research at Yale University and nationally. Continued scientific growth will benefit from activities related to research mentoring and participation in research review and advisory group participation. Additionally, the PI will continue her contributions to the alcoholism field through clinical research on psychotherapeutic interventions, pharmacotherapy development, and human bio-behavioral laboratory studies. The reciprocal influence of alcohol and tobacco use will be considered in this program of research. As an example, the research plan presents a R01 funded study of naltrexone and BASICS counseling to reduce heavy drinking by young adults ages 18-25. This study integrates information on naltrexone derived from basic research, human laboratory studies, survey studies, and clinical trials to optimize its use for young adults who receive brief counseling to motivate and teach skills for reducing their drinking. Demonstration of the efficacy of naltrexone in this population will provide the essential information for its adoption by college counseling centers and other health care settings committed to reducing the risk of heavy drinking in young adults. Ultimately, early intention during this critical period may have long term benefits by altering trajectories of drinking. Plans for future research include secondary analyses of existing clinical trials, using human laboratory paradigms to screen new medications for alcohol dependence and clinical trials of promising compounds. PUBLIC HEALTH RELEVANCE: An interdisciplinary approach to understanding and addressing hazardous alcohol use and alcohol dependence has the potential to substantially improve the effectiveness of prevention and treatment of alcohol dependence. This award will help train new investigators in interdisciplinary alcohol research.