The role of complement proteins in cardiovascular disease

补体蛋白在心血管疾病中的作用

基本信息

批准号：
7860993
负责人：
AKIRA TAKASHIMA
金额：
$ 65.5万
依托单位：
UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2011-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7860993
关键词：
Allergic Antigen-Antibody Complex Applications Grants Area Autoimmune Process Biological Assay Biological Markers Biology Biomedical Research Blood Cancer Grant Supplements (P30)Cardiovascular Diseases Centers of Research Excellence Clinical Clinical Medicine Collaborations Communities Complement Complement Activation Development Disease Doctor of Philosophy Economics Educational Activities Environment Faculty Floor Functional disorder Funding Genetic Goals Graduate Education Graft Rejection Grant Growth Health Health education Hematological Disease Hematopoietic Hemolytic-Uremic Syndrome Hispanics Human Human Biology Immune response Immunity Immunology Immunosuppressive Agents Individual Inherited Institutes Institution Interdisciplinary Study Knowledge Laboratories Leadership Link Mediating Medical Medical Microbiology Medicine Microbiology Mission Molecular National Heart, Lung, and Blood Institute Natural Immunity Ohio Organ Transplantation Pathology Phase Physicians Plasma Proteins Play Positioning Attribute Proteins Publications Reagent Recruitment Activity Research Research Infrastructure Research Personnel Research Project Grants Role Schedule Scientist Services System Technology Therapeutic Training Training and Education Translating Translational Research Translations Trustees United States Universities Woman Work career development clinical application college commercialization design frontier genetic regulatory protein graduate student innovation instrument interest member next generation novel pathogen professor programs rat Piga protein research and development square foot symposium therapeutic target translational medicine

项目摘要

DESCRIPTION (provided by applicant): We request funds through the P30 grant mechanism (RFA-OD-09-005) to recruit Viviana Ferreira, Ph.D., to the Department of Medical Microbiology and Immunology at the University of Toledo College of Medicine as a tenure-track Assistant Professor. Dr. Ferreira's recruitment has already been approved by the University Board of Trustees and she Is scheduled to join our department In July, 2009. Dr. Ferreira Is a promising junior investigator with special expertise in complement regulatory proteins which play pathogenic roles In a number of inherited and acquired blood diseases. Her research program has been always directed toward improvement of human health - In fact, her recent work has unveiled novel pathogenic mechanisms of atypical hemolytic uremic syndrome and paroxysmal nocturnal hemoglobinuria. Thus, her research area is directly relevant to the scope and mission of the National Heart Lung and Blood Institute (NHLBI). Dr. Ferreira is a Hispanic woman with advanced education and training and an outstanding publication record. Thus, her recruitment broadens the diversity of the faculty body in our institution. Finally, Dr. Ferreira's expertise In the complement system fits perfectly with ongoing research projects in our department focused on Innate and adaptive Immunity, leading to strategic and synergistic growth of our overall multi-disciplinary translational research program. The requested funds will be used not only to hire Dr. Ferreira, but also to create four additional positions for highly educated Individuals and to equip her laboratory with Instruments and reagents manufactured by domestic companies. In summary, we believe that the proposed hiring of Dr. Viviana Ferreira will boost local and national economic growth, establish the scientific/technological advantage of the United States in an Important clinical/scientific field, and broaden the diversity of our biomedical research community. We are recruiting Viviana Ferreira, Ph.D., to the Dept. of Medical Microbiology and Immunology at the University of Toledo as a tenure-track Assistant Professor. Dr. Ferreira studies special proteins in the blood known as "complement regulatory proteins," which play pathogenic roles in a number of Inherited and acquired blood diseases. Her expertise in the complement system fits perfectly with ongoing research projects in our department, thus, leading to synergistic expansion of our multi-disciplinary translational research program

描述（由申请人提供）：我们通过P30赠款机制（RFA-OD-09-005）索取资金，以招募Viviana Ferreira博士，向托莱多大学医学院医学学院医学微生物学和免疫学系招募资金。 Ferreira博士的招聘已经获得了大学董事会的批准，她计划于2009年7月加入我们的部门。Ferreira博士是一名有前途的初级调查员，具有补充调节蛋白的专业知识，在许多遗传和获得的血液疾病中扮演着致病的角色。她的研究计划始终是针对改善人类健康的 - 实际上，她最近的工作揭示了非典型溶血性尿毒症综合征和阵发性夜间夜间血红蛋白尿液的新型致病机制。因此，她的研究领域与国家心脏肺和血液研究所（NHLBI）的范围和任务直接相关。费雷拉（Ferreira）博士是一位具有高级教育和培训的西班牙裔女性，并且出色的出版记录。因此，她的招聘扩大了我们机构中教师的多样性。最后，费雷拉（Ferreira）博士在补充系统方面的专业知识完全符合我们部门正在进行的研究项目的重点是先天和适应性免疫，从而导致了我们整体多学科转化研究计划的战略和协同增长。要求的资金将不仅用于雇用Ferreira博士，而且还将为受过良好教育的个人创建四个职位，并为她的实验室配备由国内公司制造的仪器和试剂。总而言之，我们认为，拟议的Viviana Ferreira博士将在重要的临床/科学领域中促进当地和国家经济增长，建立美国的科学/技术优势，并扩大我们生物医学研究社区的多样性。我们正在招募Viviana Ferreira博士，攻读托莱多大学的医学微生物学和免疫学系，担任终身助理助理教授。 Ferreira博士研究了称为“补体调节蛋白”的血液中的特殊蛋白质，该蛋白在许多遗传和获得的血液疾病中起致病作用。她在补充系统中的专业知识完全符合我们部门正在进行的研究项目，从而导致我们的多学科翻译研究计划的协同扩展