The role of complement proteins in cardiovascular disease

补体蛋白在心血管疾病中的作用

• 批准号: 7860993
• 负责人: AKIRA TAKASHIMA
• 金额: $ 65.5万
• 依托单位: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7860993
• 关键词: Allergic; Antigen-Antibody Complex; Applications Grants; Area; Autoimmune Process; Biological Assay; Biological Markers; Biology; Biomedical Research; Blood; Cancer Grant Supplements (P30); Cardiovascular Diseases; Centers of Research Excellence; Clinical; Clinical Medicine; Collaborations; Communities; Complement; Complement Activation; Development; Disease; Doctor of Philosophy; Economics; Educational Activities; Environment; Faculty; Floor; Functional disorder; Funding; Genetic; Goals; Graduate Education; Graft Rejection; Grant; Growth; Health; Health education; Hematological Disease; Hematopoietic; Hemolytic-Uremic Syndrome; Hispanics; Human; Human Biology; Immune response; Immunity; Immunology; Immunosuppressive Agents; Individual; Inherited; Institutes; Institution; Interdisciplinary Study; Knowledge; Laboratories; Leadership; Link; Mediating; Medical; Medical Microbiology; Medicine; Microbiology; Mission; Molecular; National Heart, Lung, and Blood Institute; Natural Immunity; Ohio; Organ Transplantation; Pathology; Phase; Physicians; Plasma Proteins; Play; Positioning Attribute; Proteins; Publications; Reagent; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Role; Schedule; Scientist; Services; System; Technology; Therapeutic; Training; Training and Education; Translating; Translational Research; Translations; Trustees; United States; Universities; Woman; Work; career development; clinical application; college; commercialization; design; frontier; genetic regulatory protein; graduate student; innovation; instrument; interest; member; next generation; novel; pathogen; professor; programs; rat Piga protein; research and development; square foot; symposium; therapeutic target; translational medicine

DESCRIPTION (provided by applicant): We request funds through the P30 grant mechanism (RFA-OD-09-005) to recruit Viviana Ferreira, Ph.D., to the Department of Medical Microbiology and Immunology at the University of Toledo College of Medicine as a tenure-track Assistant Professor. Dr. Ferreira's recruitment has already been approved by the University Board of Trustees and she Is scheduled to join our department In July, 2009. Dr. Ferreira Is a promising junior investigator with special expertise in complement regulatory proteins which play pathogenic roles In a number of inherited and acquired blood diseases. Her research program has been always directed toward improvement of human health - In fact, her recent work has unveiled novel pathogenic mechanisms of atypical hemolytic uremic syndrome and paroxysmal nocturnal hemoglobinuria. Thus, her research area is directly relevant to the scope and mission of the National Heart Lung and Blood Institute (NHLBI). Dr. Ferreira is a Hispanic woman with advanced education and training and an outstanding publication record. Thus, her recruitment broadens the diversity of the faculty body in our institution. Finally, Dr. Ferreira's expertise In the complement system fits perfectly with ongoing research projects in our department focused on Innate and adaptive Immunity, leading to strategic and synergistic growth of our overall multi-disciplinary translational research program. The requested funds will be used not only to hire Dr. Ferreira, but also to create four additional positions for highly educated Individuals and to equip her laboratory with Instruments and reagents manufactured by domestic companies. In summary, we believe that the proposed hiring of Dr. Viviana Ferreira will boost local and national economic growth, establish the scientific/technological advantage of the United States in an Important clinical/scientific field, and broaden the diversity of our biomedical research community. We are recruiting Viviana Ferreira, Ph.D., to the Dept. of Medical Microbiology and Immunology at the University of Toledo as a tenure-track Assistant Professor. Dr. Ferreira studies special proteins in the blood known as "complement regulatory proteins," which play pathogenic roles in a number of Inherited and acquired blood diseases. Her expertise in the complement system fits perfectly with ongoing research projects in our department, thus, leading to synergistic expansion of our multi-disciplinary translational research program

描述（由申请人提供）：我们通过P30赠款机制（RFA-OD-09-005）申请资金，以招募Viviana Ferreira博士，2002年，他被任命为托莱多大学医学院医学微生物学和免疫学系的终身助理教授。费雷拉博士的招聘已经得到了大学董事会的批准她将于2009年7月加入我们系.费雷拉博士是一位很有前途的初级研究员在补体调节蛋白方面有着特殊的专长这种蛋白在许多遗传性和获得性血液疾病中起着致病作用。她的研究计划一直致力于改善人类健康-事实上，她最近的工作揭示了非典型溶血性尿毒综合征和阵发性睡眠性血红蛋白尿症的新致病机制。因此，她的研究领域是直接相关的范围和国家心肺和血液研究所（NHLBI）的使命。费雷拉博士是一位西班牙裔妇女，受过高等教育和培训，有着出色的出版记录。因此，她的招聘扩大了我们机构教师队伍的多样性。最后，Ferreira博士在补体系统方面的专业知识与我们部门正在进行的专注于先天和适应性免疫的研究项目完美契合，从而实现了我们整个多学科转化研究计划的战略和协同增长。所申请的资金不仅将用于聘请Ferreira博士，还将为受过高等教育的个人创造四个额外的职位，并为她的实验室配备国内公司生产的仪器和试剂。总之，我们相信，Viviana Ferreira博士的提议将促进当地和国家的经济增长，建立美国在重要临床/科学领域的科学/技术优势，并扩大我们生物医学研究界的多样性。 我们要招募薇薇安娜·费雷拉博士到部门。在托莱多大学医学微生物学和免疫学系担任终身助理教授。Ferreira博士研究血液中被称为“补体调节蛋白”的特殊蛋白质，这些蛋白质在许多遗传性和获得性血液疾病中起致病作用。她在补体系统方面的专业知识与我们部门正在进行的研究项目完全吻合，从而导致我们的多学科转化研究计划的协同扩展