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The role of complement proteins in cardiovascular disease

补体蛋白在心血管疾病中的作用

基本信息

批准号：
7935343
负责人：
AKIRA TAKASHIMA
金额：
$ 59.48万
依托单位：
UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7935343
关键词：
Allergic Antigen-Antibody Complex Applications Grants Area Autoimmune Process Biological Assay Biological Markers Biology Biomedical Research Blood Cancer Grant Supplements (P30)Cardiovascular Diseases Centers of Research Excellence Clinical Clinical Medicine Collaborations Communities Complement Complement Activation Development Disease Doctor of Philosophy Economics Educational Activities Environment Faculty Floor Functional disorder Funding Genetic Goals Graduate Education Graft Rejection Grant Growth Health Health education Hematological Disease Hematopoietic Hemolytic-Uremic Syndrome Hispanics Human Human Biology Immune response Immunity Immunology Immunosuppressive Agents Individual Inherited Institutes Institution Interdisciplinary Study Knowledge Laboratories Leadership Link Mediating Medical Medical Microbiology Medicine Microbiology Mission Molecular National Heart, Lung, and Blood Institute Natural Immunity Ohio Organ Transplantation Pathology Phase Physicians Plasma Proteins Play Positioning Attribute Proteins Publications Reagent Recruitment Activity Research Research Infrastructure Research Personnel Research Project Grants Role Schedule Scientist Services Technology Therapeutic Training Training and Education Translating Translational Research Translations Trustees United States Universities Woman Work adaptive immunity career development clinical application college commercialization complement system design frontier genetic regulatory protein graduate student innovation instrument interest member next generation novel pathogen professor programs rat Piga protein research and development square foot symposium therapeutic target translational medicine

项目摘要

DESCRIPTION (provided by applicant): We request funds through the P30 grant mechanism (RFA-OD-09-005) to recruit Viviana Ferreira, Ph.D., to the Department of Medical Microbiology and Immunology at the University of Toledo College of Medicine as a tenure-track Assistant Professor. Dr. Ferreira's recruitment has already been approved by the University Board of Trustees and she Is scheduled to join our department In July, 2009. Dr. Ferreira Is a promising junior investigator with special expertise in complement regulatory proteins which play pathogenic roles In a number of inherited and acquired blood diseases. Her research program has been always directed toward improvement of human health - In fact, her recent work has unveiled novel pathogenic mechanisms of atypical hemolytic uremic syndrome and paroxysmal nocturnal hemoglobinuria. Thus, her research area is directly relevant to the scope and mission of the National Heart Lung and Blood Institute (NHLBI). Dr. Ferreira is a Hispanic woman with advanced education and training and an outstanding publication record. Thus, her recruitment broadens the diversity of the faculty body in our institution. Finally, Dr. Ferreira's expertise In the complement system fits perfectly with ongoing research projects in our department focused on Innate and adaptive Immunity, leading to strategic and synergistic growth of our overall multi-disciplinary translational research program. The requested funds will be used not only to hire Dr. Ferreira, but also to create four additional positions for highly educated Individuals and to equip her laboratory with Instruments and reagents manufactured by domestic companies. In summary, we believe that the proposed hiring of Dr. Viviana Ferreira will boost local and national economic growth, establish the scientific/technological advantage of the United States in an Important clinical/scientific field, and broaden the diversity of our biomedical research community. We are recruiting Viviana Ferreira, Ph.D., to the Dept. of Medical Microbiology and Immunology at the University of Toledo as a tenure-track Assistant Professor. Dr. Ferreira studies special proteins in the blood known as "complement regulatory proteins," which play pathogenic roles in a number of Inherited and acquired blood diseases. Her expertise in the complement system fits perfectly with ongoing research projects in our department, thus, leading to synergistic expansion of our multi-disciplinary translational research program

描述（由申请人提供）：我们通过 P30 拨款机制 (RFA-OD-09-005) 申请资金，以招募 Viviana Ferreira 博士到托莱多大学医学院医学微生物学和免疫学系担任终身教授助理教授。 Ferreira 博士的招聘已获得大学董事会的批准，她计划于 2009 年 7 月加入我们系。Ferreira 博士是一位有前途的初级研究员，在补体调节蛋白方面拥有特殊的专业知识，这些蛋白在许多遗传性和获得性血液疾病中发挥致病作用。她的研究项目始终致力于改善人类健康——事实上，她最近的工作揭示了非典型溶血性尿毒症综合征和阵发性睡眠性血红蛋白尿症的新致病机制。因此，她的研究领域与国家心肺和血液研究所 (NHLBI) 的范围和使命直接相关。费雷拉博士是一位西班牙裔女性，接受过高等教育和培训，并拥有出色的出版记录。因此，她的招聘扩大了我们机构教师队伍的多样性。最后，Ferreira 博士在补体系统方面的专业知识与我们部门正在进行的先天性和适应性免疫研究项目完美契合，从而导致我们整个多学科转化研究项目的战略和协同增长。所申请的资金不仅将用于雇用费雷拉博士，还将用于为受过高等教育的个人设立四个额外职位，并为她的实验室配备国内公司制造的仪器和试剂。总之，我们相信聘用 Viviana Ferreira 博士将促进地方和国家经济增长，确立美国在重要临床/科学领域的科学/技术优势，并扩大我们生物医学研究界的多样性。我们正在托莱多大学医学微生物学和免疫学系招聘 Viviana Ferreira 博士担任终身教授助理教授。费雷拉博士研究血液中称为“补体调节蛋白”的特殊蛋白质，这些蛋白质在许多遗传性和获得性血液疾病中发挥致病作用。她在补体系统方面的专业知识与我们部门正在进行的研究项目完美契合，从而导致我们的多学科转化研究项目的协同扩展