The Forsyth Core Center for Discovery at the Host-Biofilm Interface

描述（由申请人提供）：福赛斯研究所的第二个世纪将看到令人兴奋的新变化的位置，研究机会和资源的可用性。在2010年，福赛斯，在口腔和颅面研究的世界领导者将搬迁到剑桥，马萨诸塞州。在新的网站上未承诺的增长空间是针对一个新的发现中心在主机生物膜接口（CHBI）。CHBI将利用现有的福赛斯科学家团队，通过将他们的专业知识集中在宿主和生物膜的关系上，已经在探索免疫和微生物的特征和相互作用。CHBI还将为招募2名新培训的教师提供基础，根据P30机制，他们将为宿主-生物膜界面的探索带来新的专业知识，观点和技术技能。我们将集中招募接受以下新兴主题培训的个人：1）上皮-微生物相互作用; 2）使用无菌小鼠模型进行微生物定植的个体发生; 3）建立和维持免疫系统; 4）先天性和适应性免疫反应之间的相互作用。新的CHBI教师将获得终身教职助理成员的任命，将有基本上100%的保护研究时间，并将提供启动资金（研究员和技术人员，用品，设备，旅行和其他研究需求的五年工资）。P30支持的试点赠款将集中在涉及和/或由新的CHBI教师领导的协作和多学科CHBI项目。通过高级工作人员和CHBI指导委员会的指导，参加研讨会，以及通过哈佛CTSC Catalyst网络（包括Catalyst的试点赠款计划）促进机构间合作，将重点放在新调查员的职业发展上。认识到在职业生涯早期阶段需要持续的支持，福赛斯将提供额外3年的工资和技术支持。福赛斯还将承担行政支持、招聘和空间改造的费用。我们的目标是通过在宿主-生物膜界面进行集中调查，部分通过纳入新教师的观点，以及通过为他们的成熟创造一个环境，以扩大CHBI的科学范围和影响。 公共卫生相关性：人体内的细菌数量是我们体内细胞数量的10倍。我们与这些微生物中的大多数和谐相处;然而，其中一些细菌可能会成为致病菌。这项工作的目标是招募和发展两名新研究人员的职业生涯，从新的角度探索人类和我们的细菌乘客通常如何共存，以及当疾病发生时会发生什么变化。

DESCRIPTION (provided by applicant): The Forsyth Institute's second century will see exciting new changes in location, research opportunities and resource availability. In 2010, Forsyth, the world leader in oral and craniofacial research will relocate to Cambridge, MA. The uncommitted growth space at the new site is being targeted for a new Center for Discovery at the Host-Biofilm Interface (CHBI). The CHBI will take advantage of existing teams of Forsyth scientists already exploring immune and microbial characteristics and interactions by focusing their expertise at the nexus of host and biofilm. The CHBI will also provide the base for recruiting 2 newly trained faculty, under the P30 mechanism, who will bring new expertise, perspectives, and technical skills to the exploration of the host-biofilm interface. We will concentrate our recruitment on individuals trained in emerging themes of 1) epithelial-microbial interactions; 2) ontogeny of microbial colonization, using germfree mouse models; 3) establishment and maintenance of commensalism; and 4) cross-talk between innate and adaptive immune responses. New CHBI faculty will be given tenure-track Assistant Member of Staff appointments, will have essentially 100% protected research time, and will be provided with start-up funds (five total years of salary for investigator and technician, supplies, equipment, travel and other research needs). P30-supported pilot grants will focus on collaborative and multi-disciplinary CHBI projects involving and/or led by new CHBI faculty. A strong emphasis will be placed on new investigator career development through mentoring by senior staff and the CHBI Steering Committee, participation in workshops, and by promoting interinstitutional collaborations through the Harvard CTSC Catalyst network, including Catalyst's pilot grant program. Recognizing the need for sustained support during the early career phase, Forsyth will provide salary and technical support for an additional 3 years. Forsyth will also underwrite costs for administrative support, recruitment, and space renovation. Our goals are to expand the scientific reach and impact of the CHBI by focused investigation at the host-biofilm interface, in part, by including the perspectives of new faculty, as well as by creating an environment for their maturation into fully independent research careers. PUBLIC HEALTH RELEVANCE: Humans are colonized by 10 times more bacteria than there are cells in our bodies. We live in harmony with most of these microbes; however, some of these bacteria may become pathogenic. The goal of this effort is to recruit and develop the careers of two new investigators to explore from new perspectives how humans and our bacterial passengers normally coexist and what changes when disease occurs.