The Forsyth Core Center for Discovery at the Host-Biofilm Interface

宿主-生物膜界面的福赛斯核心发现中心

• 批准号: 7860751
• 负责人: Daniel James Smith
• 金额: $ 92.04万
• 依托单位: ADA FORSYTH INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-17 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7860751
• 关键词: Appointment; Bacteria; Cells; Center Core Grants; Characteristics; Collaborations; Disease; Educational workshop; Environment; Epithelial; Equipment and Supplies; Faculty; Funding; Gap Junctions; Goals; Grant; Growth; Human; Immune; Immune response; Individual; Institutes; Investigation; Life; Location; Maintenance; Mentors; Microbe; Microbial Biofilms; Oral; Phase; Recruitment Activity; Research; Research Personnel; Resources; Scientist; Site; Symbiosis; Time; Training; Travel; Wages; base; career; career development; catalyst; cost; craniofacial; insight; member; microbial; microbial colonization; microorganism interaction; mouse model; programs; public health relevance; skills; tool

DESCRIPTION (provided by applicant): The Forsyth Institute's second century will see exciting new changes in location, research opportunities and resource availability. In 2010, Forsyth, the world leader in oral and craniofacial research will relocate to Cambridge, MA. The uncommitted growth space at the new site is being targeted for a new Center for Discovery at the Host-Biofilm Interface (CHBI). The CHBI will take advantage of existing teams of Forsyth scientists already exploring immune and microbial characteristics and interactions by focusing their expertise at the nexus of host and biofilm. The CHBI will also provide the base for recruiting 2 newly trained faculty, under the P30 mechanism, who will bring new expertise, perspectives, and technical skills to the exploration of the host-biofilm interface. We will concentrate our recruitment on individuals trained in emerging themes of 1) epithelial-microbial interactions; 2) ontogeny of microbial colonization, using germfree mouse models; 3) establishment and maintenance of commensalism; and 4) cross-talk between innate and adaptive immune responses. New CHBI faculty will be given tenure-track Assistant Member of Staff appointments, will have essentially 100% protected research time, and will be provided with start-up funds (five total years of salary for investigator and technician, supplies, equipment, travel and other research needs). P30-supported pilot grants will focus on collaborative and multi-disciplinary CHBI projects involving and/or led by new CHBI faculty. A strong emphasis will be placed on new investigator career development through mentoring by senior staff and the CHBI Steering Committee, participation in workshops, and by promoting interinstitutional collaborations through the Harvard CTSC Catalyst network, including Catalyst's pilot grant program. Recognizing the need for sustained support during the early career phase, Forsyth will provide salary and technical support for an additional 3 years. Forsyth will also underwrite costs for administrative support, recruitment, and space renovation. Our goals are to expand the scientific reach and impact of the CHBI by focused investigation at the host-biofilm interface, in part, by including the perspectives of new faculty, as well as by creating an environment for their maturation into fully independent research careers. PUBLIC HEALTH RELEVANCE: Humans are colonized by 10 times more bacteria than there are cells in our bodies. We live in harmony with most of these microbes; however, some of these bacteria may become pathogenic. The goal of this effort is to recruit and develop the careers of two new investigators to explore from new perspectives how humans and our bacterial passengers normally coexist and what changes when disease occurs.

描述（由申请人提供）：福赛斯研究所的第二世纪将看到令人兴奋的位置，研究机会和资源可用性的新变化。 2010年，福赛斯（Forsyth），口头和颅面研究的世界领导者将搬到马萨诸塞州的剑桥。新地点的未建立的增长空间是针对宿主双膜界面（CHBI）的新发现中心的目标。 CHBI将利用现有的Forsyth科学家团队，通过将其专业知识集中在宿主和生物膜的Nexus上，从而探索免疫和微生物特征和相互作用。 CHBI还将为根据P30机制招募2位新训练的教职员工提供基础，这些教师将带来新的专业知识，观点和技术技能，以探索宿主 - 双膜界面。我们将招聘专注于接受以1）上皮微生物相互作用的新兴主题培训的个体； 2）使用无毛小鼠模型的微生物定植的个体发育； 3）建立和维持共生主义； 4）先天和适应性免疫反应之间的串扰。新的CHBI教职员工将获得任职期限的任期助理成员，基本上将拥有100％受保护的研究时间，并将提供启动资金（调查员和技术人员，用品，设备，旅行和其他研究需求的总薪水为五年）。 P30支持的飞行员赠款将专注于由新CHBI教师涉及和/或领导的合作和多学科的CHBI项目。通过高级职员和CHBI指导委员会的指导，参加研讨会，以及通过哈佛CTSC催化剂网络（包括Catalyst的飞行员赠款计划）促进机构间合作，将强烈重视新的研究者职业发展。福赛斯（Forsyth）认识到在早期职业阶段需要持续支持的必要性，将在3年中提供薪水和技术支持。福赛斯还将承保行政支持，招聘和空间翻新成本。我们的目标是通过包括新教师的观点，以及创造一个使其成熟到完全独立的研究职业的环境，通过重点调查在寄主双膜界面的重点调查来扩大CHBI的科学影响和影响。 公共卫生相关性：人类被殖民的细菌殖民比我们体内的细胞多10倍。我们与大多数这些微生物和谐相处。但是，其中一些细菌可能会变为致病性。这项努力的目的是招募和发展两个新研究人员的职业，以从新的角度探索人类和我们的细菌乘客通常是在疾病发生时如何共存以及发生什么变化的。