The Forsyth Core Center for Discovery at the Host-Biofilm Interface

宿主-生物膜界面的福赛斯核心发现中心

• 批准号: 7934067
• 负责人: Daniel James Smith
• 金额: $ 92.04万
• 依托单位: ADA FORSYTH INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-17 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7934067
• 关键词: Appointment; Bacteria; Cells; Center Core Grants; Characteristics; Collaborations; Disease; Educational workshop; Environment; Epithelial; Equipment and Supplies; Faculty; Funding; Gap Junctions; Goals; Grant; Growth; Human; Immune; Immune response; Individual; Institutes; Investigation; Life; Location; Maintenance; Mentors; Microbe; Microbial Biofilms; Oral; Phase; Recruitment Activity; Research; Research Personnel; Resources; Scientist; Site; Symbiosis; Time; Training; Travel; Wages; base; career; career development; catalyst; cost; craniofacial; insight; member; microbial; microbial colonization; microorganism interaction; mouse model; programs; public health relevance; skills; tool

DESCRIPTION (provided by applicant): The Forsyth Institute's second century will see exciting new changes in location, research opportunities and resource availability. In 2010, Forsyth, the world leader in oral and craniofacial research will relocate to Cambridge, MA. The uncommitted growth space at the new site is being targeted for a new Center for Discovery at the Host-Biofilm Interface (CHBI). The CHBI will take advantage of existing teams of Forsyth scientists already exploring immune and microbial characteristics and interactions by focusing their expertise at the nexus of host and biofilm. The CHBI will also provide the base for recruiting 2 newly trained faculty, under the P30 mechanism, who will bring new expertise, perspectives, and technical skills to the exploration of the host-biofilm interface. We will concentrate our recruitment on individuals trained in emerging themes of 1) epithelial-microbial interactions; 2) ontogeny of microbial colonization, using germfree mouse models; 3) establishment and maintenance of commensalism; and 4) cross-talk between innate and adaptive immune responses. New CHBI faculty will be given tenure-track Assistant Member of Staff appointments, will have essentially 100% protected research time, and will be provided with start-up funds (five total years of salary for investigator and technician, supplies, equipment, travel and other research needs). P30-supported pilot grants will focus on collaborative and multi-disciplinary CHBI projects involving and/or led by new CHBI faculty. A strong emphasis will be placed on new investigator career development through mentoring by senior staff and the CHBI Steering Committee, participation in workshops, and by promoting interinstitutional collaborations through the Harvard CTSC Catalyst network, including Catalyst's pilot grant program. Recognizing the need for sustained support during the early career phase, Forsyth will provide salary and technical support for an additional 3 years. Forsyth will also underwrite costs for administrative support, recruitment, and space renovation. Our goals are to expand the scientific reach and impact of the CHBI by focused investigation at the host-biofilm interface, in part, by including the perspectives of new faculty, as well as by creating an environment for their maturation into fully independent research careers. PUBLIC HEALTH RELEVANCE: Humans are colonized by 10 times more bacteria than there are cells in our bodies. We live in harmony with most of these microbes; however, some of these bacteria may become pathogenic. The goal of this effort is to recruit and develop the careers of two new investigators to explore from new perspectives how humans and our bacterial passengers normally coexist and what changes when disease occurs.

描述（由申请人提供）：福赛斯研究所的第二个世纪将在地点、研究机会和资源可用性方面看到令人兴奋的新变化。 2010 年，口腔和颅面研究领域的世界领导者 Forsyth 将搬迁至马萨诸塞州剑桥。新地点未使用的增长空间将被用于在宿主生物膜界面（CHBI）建立一个新的发现中心。 CHBI 将利用福赛斯科学家现有团队的优势，将他们的专业知识集中在宿主和生物膜的关系上，从而探索免疫和微生物特征及相互作用。 CHBI 还将为在 P30 机制下招募 2 名新培训的教师提供基础，他们将为宿主-生物膜界面的探索带来新的专业知识、观点和技术技能。我们将集中招募受过以下新兴主题培训的个人：1）上皮-微生物相互作用； 2）微生物定植的个体发育，使用无菌小鼠模型； 3）共生主义的建立和维持； 4）先天免疫反应和适应性免疫反应之间的串扰。新的 CHBI 教员将获得终身助理助理成员任命，将拥有基本上 100% 受保护的研究时间，并将获得启动资金（总共五年的工资，用于研究者和技术人员、用品、设备、旅行和其他研究需求）。 P30 支持的试点拨款将重点关注涉及新 CHBI 教师和/或由新 CHBI 教师领导的协作和多学科 CHBI 项目。将通过高级工作人员和 CHBI 指导委员会的指导、参加研讨会以及通过哈佛 CTSC Catalyst 网络（包括 Catalyst 的试点资助计划）促进机构间合作，重点关注新研究者的职业发展。认识到早期职业阶段需要持续支持，福赛斯将提供额外 3 年的薪资和技术支持。福赛斯还将承担行政支持、招聘和空间翻新的费用。我们的目标是通过对宿主生物膜界面进行重点研究来扩大 CHBI 的科学范围和影响力，部分是通过纳入新教师的观点，以及为他们成熟进入完全独立的研究职业创造环境。 公共卫生相关性：人类体内的细菌数量是我们体内细胞数量的 10 倍。我们与大多数微生物和谐相处；然而，其中一些细菌可能会致病。这项工作的目标是招募和发展两名新研究人员的职业生涯，以从新的角度探索人类和细菌乘客通常如何共存以及疾病发生时会发生什么变化。

项目成果

Interleukin-6 induces the generation of IL-10-producing Tr1 cells and suppresses autoimmune tissue inflammation.

• DOI: 10.1016/j.jaut.2012.07.009
• 发表时间: 2013-02
• 期刊: Journal of autoimmunity
• 影响因子: 12.8
• 作者: Jin JO;Han X;Yu Q
• 通讯作者: Yu Q

Interleukin-6 inhibits apoptosis of exocrine gland tissues under inflammatory conditions.

• DOI: 10.1016/j.cyto.2015.07.027
• 发表时间: 2015-12
• 期刊: Cytokine
• 影响因子: 3.8
• 作者: Zhou J;Jin JO;Patel ES;Yu Q
• 通讯作者: Yu Q

Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples.

• DOI: 10.1186/gb-2012-13-6-r42
• 发表时间: 2012-06-14
• 期刊: Genome biology
• 影响因子: 12.3
• 作者: Segata N;Haake SK;Mannon P;Lemon KP;Waldron L;Gevers D;Huttenhower C;Izard J
• 通讯作者: Izard J

Interleukin-7 enhances the Th1 response to promote the development of Sjögren's syndrome-like autoimmune exocrinopathy in mice.

• DOI: 10.1002/art.38007
• 发表时间: 2013-08
• 期刊: ARTHRITIS AND RHEUMATISM
• 作者: Jin, Jun-O;Kawai, Toshihisa;Cha, Seunghee;Yu, Qing
• 通讯作者: Yu, Qing

Endogenous programmed death ligand-1 restrains the development and onset of Sjӧgren's syndrome in non-obese diabetic mice.

内源性编程的死亡配体1限制了非肥胖糖尿病小鼠中Sjӧgren综合征的发育和发作。

• DOI: 10.1038/srep39105
• 发表时间: 2016-12-14
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Zhou J;Jin JO;Kawai T;Yu Q
• 通讯作者: Yu Q