GENETICS CORE

GI遗传学核心将在促进获得遗传工具方面发挥关键作用， 研究项目。遗传操作是从生物建模到建立 以及测试正常和临床相关疾病状态中的关键分子信号传导途径。 基因工具非常活跃，每年都有新技术上线。遗传学 核心将作为一个枢纽，为当前，新兴和未来的基因技术，建议和帮助 中心成员适当地评估和跟上这些往往是破坏性的科学进步。的 Genetics Core将平衡其在当前（如siRNA、体内成像、微阵列、小鼠ES 细胞），新兴（如通过下一代测序和斑马鱼的转录组分析 基因敲除）和不久的将来（如新的DNA递送平台，包括二氧化硅纳米颗粒）遗传学 工具.作为获取遗传技术最新信息的枢纽，该核心将代表一个 通过其培训机会、网站、 个人咨询。遗传学核心主任（Stephen C.埃克博士，要求15%的时间） 是马约诊所的新成员，拥有丰富的分子遗传学专业知识。目标的实现 这个核心，兼职支持生物信息学，生物统计学和遗传学指令的要求。

The Gl Genetics Core will serve a critical role in facilitating access to genetic tools for Center-based research projects. Genetic manipulation is a critical approach from biological modeling to establishing and testing critical molecular signaling pathways in both the normal and clinically relevant disease state. Genetic tools are extremely dynamic, with new technologies coming on line every year. The Genetics Core will serve as a hub for current, emerging and future genetic technologies, advising and helping Center members properly assess and keep abreast of these often disruptive scientific advances. The Genetics Core will balance its efforts on current (such as siRNA, in vivo imaging, microarray, mouse ES cells), emerging (such as transcriptome analyses via next-generation sequencing and zebrafish knockouts) and near-future (such as new DNA delivery platforms including silica nanopartides) genetics tools. As a hub for access to the latest information on genetics technologies, this core will represent an important and central interface to this dynamic research area through its training opportunities, Web site and individual consultation. The Genetics Core Director (Stephen C. Ekker, Ph.D., 15% time requested) is a recent recruit to the Mayo Clinic with extensive molecular genetics expertise. To achieve the goal of this Core, part-time support for bioinformatics, biostatistics and genetics instruction is requested.