GENETICS CORE

遗传学核心

• 批准号: 7760766
• 负责人: Stephen Carl Ekker
• 金额: $ 23.19万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7760766
• 关键词: Advisory Committees; Animal Model; Applications Grants; Area; Arts; Bioinformatics; Biological Models; Biometry; Clinic; Complement; Consult; Consultations; DNA delivery; Disease; Doctor of Philosophy; Education; Educational process of instructing; Electronic Mail; Equilibrium; Evaluation; Exhibits; Funding; Future; Gastroenterology; Gene Expression Profile; Gene Expression Regulation; Genetic; Genetic Variation; Genomics; Goals; Grant; Image; Individual; Instruction; Ion Channel; Knock-out; Location; Membrane; Methods; Molecular; Molecular Genetics; Mus; Paper; Physiologic pulse; Pilot Projects; Proteomics; Recruitment Activity; Research; Research Personnel; Research Project Grants; Resources; Role; Scientific Advances and Accomplishments; Scientist; Signal Pathway; Signal Transduction; Silicon Dioxide; Small Interfering RNA; Technology; Testing; Time; Training; Transgenic Mice; United States National Institutes of Health; Zebrafish; base; clinically relevant; design; embryonic stem cell; experience; genetic manipulation; genetic resource; genetic technology; in vivo; insight; knockout animal; member; new technology; next generation; receptor; repository; tool; virtual; web site

The Gl Genetics Core will serve a critical role in facilitating access to genetic tools for Center-based research projects. Genetic manipulation is a critical approach from biological modeling to establishing and testing critical molecular signaling pathways in both the normal and clinically relevant disease state. Genetic tools are extremely dynamic, with new technologies coming on line every year. The Genetics Core will serve as a hub for current, emerging and future genetic technologies, advising and helping Center members properly assess and keep abreast of these often disruptive scientific advances. The Genetics Core will balance its efforts on current (such as siRNA, in vivo imaging, microarray, mouse ES cells), emerging (such as transcriptome analyses via next-generation sequencing and zebrafish knockouts) and near-future (such as new DNA delivery platforms including silica nanopartides) genetics tools. As a hub for access to the latest information on genetics technologies, this core will represent an important and central interface to this dynamic research area through its training opportunities, Web site and individual consultation. The Genetics Core Director (Stephen C. Ekker, Ph.D., 15% time requested) is a recent recruit to the Mayo Clinic with extensive molecular genetics expertise. To achieve the goal of this Core, part-time support for bioinformatics, biostatistics and genetics instruction is requested.

GL 遗传学核心将在促进中心获得遗传工具方面发挥关键作用 研究项目。基因操作是从生物建模到建立 并测试正常和临床相关疾病状态下的关键分子信号传导途径。 遗传工具非常动态，每年都会有新技术出现。遗传学 Core 将作为当前、新兴和未来遗传技术的中心，提供建议和帮助 中心成员正确评估并及时了解这些经常具有破坏性的科学进步。这 Genetics Core 将平衡当前的工作（例如 siRNA、体内成像、微阵列、小鼠 ES 细胞），新兴的（例如通过下一代测序和斑马鱼进行转录组分析） 基因敲除）和近期（例如包括二氧化硅纳米颗粒在内的新 DNA 传递平台）遗传学 工具。作为获取遗传技术最新信息的中心，该核心将代表 通过其培训机会、网站与这个充满活力的研究领域的重要和中心接口 以及个别咨询。遗传学核心总监（Stephen C. Ekker 博士，15% 时间请求） 是梅奥诊所的新员工，拥有丰富的分子遗传学专业知识。为了实现以下目标 该核心要求为生物信息学、生物统计学和遗传学教学提供兼职支持。