CLINICAL TRIAL: HALT-C

临床试验：HALT-C

• 批准号: 7951023
• 负责人: TIMOTHY ROSS MORGAN
• 金额: $ 4.54万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951023
• 关键词: Acquired Immunodeficiency Syndrome; Affect; Age; Alcoholism; Cessation of life; Chronic Hepatitis C; Cirrhosis; Clinic; Clinical Research; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Funding; Grant; Health; Hepatitis C; Hepatitis C virus; Infection; Institution; Italy; Japan; Liver Failure; Liver diseases; Malignant neoplasm of liver; Patients; Research; Research Personnel; Resources; Source; Spain; United States National Institutes of Health; liver transplantation; men; problem drinker

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hepatitis C affects an estimated 4 million people in the U.S., with 30,000 new cases diagnosed annually (1-3). The hepatitis C virus (HCV) ranks second behind alcoholism among the causes of liver disease and is the leading reason for liver transplants (4-6). Health experts say the number of deaths from HCV may soon surpass the number attributed to AIDS (Mayo Clinic, Dec. 12, 1998). In fact, hepatitis C might be the most common cause of primary liver cancer in the developed world. In Italy, Spain, and Japan, at least half of liver cancers could be related to HCV (7). Chronic hepatitis C can cause cirrhosis, liver failure, and liver cancer (8). About 20 percent of patients develop cirrhosis within 10 to 20 years of the onset of infection (9). Men, alcoholics, patients with cirrhosis, people over age 40, and those infected for 20 to 40 years are more likely to develop HCV-related liver cancer (7).

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 丙型肝炎在美国影响约400万人，每年诊断出30,000例新病例（1-3）。 丙型肝炎病毒（HCV）在肝病的原因中仅次于酒精中毒，是肝脏移植的主要原因（4-6）。 健康专家说，HCV死亡人数可能很快超过了艾滋病的数量（Mayo Clinic，1998年12月12日）。 实际上，丙型肝炎可能是发达国家原发性肝癌的最常见原因。 在意大利，西班牙和日本，至少一半的肝癌可能与HCV有关（7）。 慢性丙型肝炎会引起肝硬化，肝衰竭和肝癌（8）。 大约20％的患者在感染发作后的10至20年内出现肝硬化（9）。 男性，酗酒者，肝硬化患者，40岁以上的患者以及20至40岁的患者更有可能患上与HCV相关的肝癌（7）。